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Figure 6

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Mutations in the Med8-Med18-Med20 submodule compromise H3K9 methylation at the centromeric dg promoter. ChIP analyses show that the level of H3K9 dimethylation at the centromeric dg promoter is reduced in med18Δ and med20Δ mutants relative to wild-type. A clr4Δ strain was processed in parallel for comparison. *P <0.003. The strains for this figure were: WT (FY498), med18Δ (MT42), med20Δ (MT26), and clr4Δ (PG3423).

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