FIGURE 4.

CnAβ^−/− mice exhibited potentiated response in β-adrenergic receptor signaling pathway. A, number of incidences of seizure found in 6–12-month-old CnAβ^−/− and CnAβ^+/+ mice during their body weight measurement was recorded. B, amount of urine retained in bladder of CnAβ^−/− and CnAβ^+/+ mice (n = 5) after sedation was determined. C, body weight of CnAβ^−/− and CnAβ^+/+ mice (n = 10–15) was determined at the times indicated. D and E, the levels of triglyceride (D) and free fatty acids (FFA; E) of CnAβ^−/− and CnAβ^+/+ mice (n = 6) upon injection of β₃-adrenergic receptor agonist CL (0.1 mg/kg) were determined at the times indicated. F, MABP of conscious CnAβ^−/− and CnAβ^+/+ mice was determined by radiotelemetry upon injection of β-adrenergic receptor agonist Iso (2 mg/kg). The time required for MABP return to resting level (dashed line) is indicated. The data presented are representative of three independent experiments with two mice per group. *, p < 0.05; #, p < 0.005.