Neurodevelopmental Actions of Leptin

Sebastien G. Bouret

doi:10.1016/j.brainres.2010.04.011

Figure 2

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Developmental actions of leptin in the forebrain

Schematic illustration representing the neurodevelopmental effects of leptin. During pre- and postnatal life, leptin appears to be required for the normal development of forebrain pathways by regulating neurogenesis and circuit formation. In addition, leptin can still affect brain plasticity in adults by causing synaptic rearrangement of excitatory and inhibitory inputs on hypothalamic neurons and by influencing cell proliferation in the hippocampus. Images used with permission [10,46,55]