PMC full text:
Published online 2014 Jan 17. doi: 10.1371/journal.pone.0084844
Table 1
Baseline characteristics by supplement allocation (N = 2,029)a.
| B vitamins | N-3 fatty acids | |||||||||
| Yes (n = 1,000) | No (n = 1,029) | P b | Yes (n = 1,025) | No (n = 1,004) | P b | |||||
| Demographic | ||||||||||
| Age, mean (SD), y | 61.1 | (8.8) | 61.4 | (8.8) | 0.42 | 61.1 | (9.1) | 61.4 | (8.6) | 0.46 |
| Female, No. (%) | 199 | (19.9) | 215 | (20.9) | 0.58 | 206 | (20.1) | 208 | (20.7) | 0.73 |
| Married/cohabiting, No. (%) | 722 | (72.2) | 753 | (73.2) | 0.71 | 737 | (71.9) | 738 | (73.5) | 0.67 |
| Post-secondary education, No. (%) | 148 | (14.8) | 170 | (16.5) | 0.29 | 162 | (15.8) | 156 | (15.5) | 0.80 |
| Employed, No. (%) | 361 | (36.1) | 367 | (35.7) | 0.75 | 382 | (37.3) | 346 | (34.5) | 0.14 |
| Foreign-born, No. (%) | 111 | (11.1) | 107 | (10.4) | 0.61 | 112 | (10.9) | 106 | (10.6) | 0.79 |
| Behavioral [No. (%)] | ||||||||||
| Current smoker | 97 | (9.7) | 100 | (9.7) | 0.99 | 99 | (9.7) | 98 | (9.8) | 0.99 |
| Former smoker | 615 | (61.5) | 623 | (60.5) | 0.65 | 615 | (60.0) | 623 | (62.1) | 0.50 |
| Heavy alcohol usec | 241 | (24.1) | 287 | (27.9) | 0.03 | 264 | (25.8) | 264 | (26.3) | 0.87 |
| Clinical (mean, SD) | ||||||||||
| Body mass index (kg/m2) | 27.6 | (4.1) | 27.4 | (3.8) | 0.42 | 27.5 | (4.1) | 27.5 | (3.8) | 0.95 |
| Diastolic blood pressure (mmHg) | 83.2 | (12.2) | 83.0 | (12.0) | 0.66 | 83.3 | (11.8) | 82.9 | (12.3) | 0.45 |
| Systolic blood pressure (mmHg) | 132.7 | (21.0) | 133.3 | (21.0) | 0.52 | 133.0 | (21.1) | 133.0 | (20.9) | 0.93 |
| Biological (median, interquartile range) | ||||||||||
| Serum folate (ng/ml) | 6.8 | (3.4) | 6.9 | (3.6) | 0.98 | 6.8 | (3.5) | 6.9 | (3.5) | 0.43 |
| Plasma vitamin B6 (nmol/L) | 37.8 | (23.6) | 38.8 | (26.0) | 0.53 | 38.7 | (24.3) | 38.1 | (24.5) | 0.71 |
| Serum vitamin B12 (pg/ml) | 363.0 | (161.0) | 372.0 | (172.0) | 0.20 | 363.0 | (170.0) | 373.0 | (165.0) | 0.18 |
| Plasma EPA+DHAd (%) | 3.8 | (2.0) | 4.0 | (2.1) | 0.26 | 3.8 | (2.1) | 3.9 | (2.0) | 0.76 |
| Cardiovascular disease history [No. (%)] | ||||||||||
| Myocardial infarction | 469 | (46.9) | 470 | (45.7) | 0.58 | 476 | (46.4) | 463 | (46.1) | 0.88 |
| Unstable angina | 282 | (28.2) | 302 | (29.4) | 0.57 | 301 | (29.4) | 283 | (28.2) | 0.56 |
| Ischemic stroke | 249 | (24.9) | 257 | (25.0) | 0.97 | 248 | (24.2) | 258 | (25.7) | 0.43 |
SI conversion: folate - to convert to nmol/L, multiply by 2.266; vitamin B6 - to convert to ng/mL, divide by 4.046; vitamin B12 - to convert to pmol//L multiply by 0.7378.
a Sample with available SF-36 quality of life data provided 2.5–5.0 y post-baseline.
b Based on chi-square tests, Student t-tests, or Wilcoxon Rank Sum tests, as appropriate.
c Defined as >20 g/d for women and >30 g/d for men.
d EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid.