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Prog Mol Biol Transl Sci. Author manuscript; available in PMC 2014 May 23.
Published in final edited form as:
Prog Mol Biol Transl Sci. 2011; 101: 1–21.
doi: 10.1016/B978-0-12-387685-0.00001-9
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H3K4me0 interacting proteins. (A) Domain architecture of H3K4me0-interacting proteins containing ADD domains. ATRX interacts with histone H3.3,96,97 and mutating the K4 residue of H3.3 significantly diminishes ATRX–H3.3 interaction.98 (B) Model of the reactions that regulate DNA methylation by Dnmt3a/3L. Recognition of H3K4me0 by the ADD domain of DNMT3 directs the DNA methylation reaction. The “m” in a red circle indicates one or more methyl groups in DNA (5mC) or histone lysines (Km).

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