Introduction—Epiphanies in Epigenetics

Xiaodong Cheng; Robert M. Blumenthal

doi:10.1016/B978-0-12-387685-0.00001-9

Fig. 3

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CpG interacting proteins (A) Domain architecture of proteins containing a CXXC domain (two copies of CxxCxxC motif). (B) Model of the H3K4 methylation reaction by MLL/SET1 proteins. CXXC domain-mediated binding to unmethylated CpGs directs the methylation of H3K4 by MLL/SET1 proteins.