Figure 4

Genomic signatures that predict the magnitude of the CD8⁺ T cell responses, using the ClaNC model. The genes identified as having a relationship to the subsequent T cell responses, as described in Figure 3, were analyzed by ClaNC to develop a predictive model of CD8⁺ T cell responses based on a subset of genes. (a) A process of leave-one-out cross-validation testing the predictive strengths of subsets of genes for ClaNC gene models. (b) The ClaNC gene models developed through cross validation on the first trial of 15 subjects was tested on both trials of 15 and 10 subjects to determine the error rates.