Figure 6

a-c, First three neocortical principal components, plotted across 57 cortical divisions ordered roughly rostral to caudal (frontal to occipital pole), are highly reproducible between brains. PC1 (Pearson r = 0.71) is selective for primary sensory and motor areas (a). PC2 (Pearson r = 0.51) is differential for specific subdivisions of the frontal, temporal and occipital poles (b), whereas PC3 (Pearson r = 0.70) is selective for the caudal portion of the frontal lobe (c). d, e, Relationship between the (x, y, z) location of sampled cortical gyri and their transcriptional similarities. Native Brain 1 MRI is shown in d with major gyri labelled (Supplementary Table 2). e, MDS applied to the same cortical samples, where distance between points reflects similarity in gene expression profiles. Median samples for major gyri are labelled. Samples cluster by lobe, and both lobe positions and gyral positions generally mirror the native spatial topography, emphasized by arrows in d and e. Inset panel in e plots the relationship (mean ± 1 s.d.) between 3D MDS-based similarity and 3D in vivo sample distance, demonstrating correlations that are stronger between proximal samples and decrease with distance. Selected gyral pairs are labelled. See Supplementary Table 2 for cortical gyrus abbreviations.