In Vivo Fluorescence Imaging and Urinary Monoamines as Surrogate Biomarkers of Disease Progression in a Mouse Model of Pheochromocytoma

Martin Ullrich; Ralf Bergmann; Mirko Peitzsch; Marc Cartellieri; Nan Qin; Monika Ehrhart-Bornstein; Norman L. Block; Andrew V. Schally; Jens Pietzsch; Graeme Eisenhofer; Stefan R. Bornstein; Christian G. Ziegler

doi:10.1210/en.2014-1431

Figure 2.

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Progression of sc tumors in male and female nude mice after sc injection of 2 × 10⁶ MPC-mCherry cells. A, Overlays of x-ray and fluorescence images (λ_Ex/Em = 600/700 nm) of a representative animal at 1 h to 29 d post injection. B, Tumor fluorescence intensities in vivo over time. C, Tumor volumes over time; data are presented as mean ± SD, (male animals, n = 10; female animals, n = 10). D, Correlation analysis between tumor volume and tumor fluorescence intensity; n = 20; confidence interval, 95%; number of XY pairs, 136; p.i., post injection; px, pixel.