Effects of Insulin-like Growth Factor-1 and Dexamethasone on Cytokine-Challenged Cartilage: Relevance to Post Traumatic Osteoarthritis

Yang Li; Yang Wang; Susanna Chubinskaya; Birgit Schoeberl; Emily Florine; Paul Kopesky; Alan J. Grodzinsky

doi:10.1016/j.joca.2014.11.006

Figure 5

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A, Percent sGAG loss from adult human ankle cartilage in response to 17-day treatments, N = 40 disks from n=5 donors (1 independent experiment per donor). B, Normalized sulfate incorporation rate during Day 15–17 for the same cartilage disks used in A above. C, Percent sGAG loss from adult human knee cartilage in response to 17-day treatments, N = 24 disks from n=3 donors (1 independent experiment per donor). D, Normalized sulfate incorporation rate during Day 15–17 of the same disks in C. Values are mean and 95% confidence interval. * vs. untreated control (p<0.0001); # vs. IL-lα alone (p<.0001); $ : p < 0.0001.