Flaviviruses, an expanding threat in public health: focus on Dengue, West Nile, and Japanese encephalitis virus

Carlo Amorin Daep; Jorge L. Muñoz-Jordán; Eliseo Alberto Eugenin

doi:10.1007/s13365-014-0285-z

Figure 4

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Flavivirus genome. The flavivirus genome consists of a single stranded positive-sense RNA encoding a polyprotein post-translationally cleaved by host proteases (sites designated by the blue arrows) and viral proteases (sites designated by green arrows). The site designated by the red arrow is cleaved by a yet to be identified protease. Processing of the polyprotein produces 3 structural (white boxes) and 7 non-structural genes (grey boxes). The prM protein is then later cleaved within the Golgi to release the M protein important for the maturation of the virus. Translation of viral RNA is controlled by the untranslated regions (UTR) located at the 5’ and 3’-ends of the RNA.