Extended Data Figure 7

(a) Correlation matrix of 56 cell types, clustered by similarity of H3K27ac profiles (high=red, low=blue). (b) Enrichment of noncoding autoimmune disease candidate causal SNPs within immune enhancers and promoters compared to background. The background expectation is based on frequency-matched control SNPs drawn from within 50kb of the candidate causal SNPs. Candidate causal SNPs that produced coding changes or were in LD with a coding variant (paired bars on the right) showed a smaller degree of enrichment in immune enhancers and promoters compared to background. (c) Overlap of PICS SNPs with H3K27ac peaks within T-cell super-enhancers. Bar plot shows overlap of PICS SNPs with H3K27ac peaks in super-enhancers in CD4⁺ T-cells, compared to random SNPs drawn from within the same super-enhancers (All CD4⁺; left bar graph). Adjacent bars show overlap to H3K27ac peaks within CD4⁺ T-cell super-enhancers that do (Stim) or do not (Unstim) increase their acetylation upon stimulation.