Table 1
Summary of the safety data after oral administration of high doses of SAG2 vaccine to foxes and raccoon dogs
| Species | No of animals, route (mean age) | SAG dose per animal | Time of observation | Specific morbidity/mortality | Virus isolation from saliva swabs | Rabies virus positive brains | Rabies virus positive salivary glands | Seroconversion | Source |
|---|---|---|---|---|---|---|---|---|---|
| Fox | 10 p.o. (6 months to 2.5 years) | 109.8 CCID50 | 183 days | 0/10 | 0/10 (D0, D1, D3, D7) | 0/10 | 0/10 | 10/10 | [26] |
| 10 p.o. (9 months) | 109 p.f.u. | 175 days | 0/10 | 0/10 (D1, D3, D6) | 0/10 | 0/10 | 10/10 | ||
| Raccoon dog | 5 p.o. instillation (6 months) | 1010.0 CCID50 | 60 days | 0/5 | 0/5 | 0/5 | 5/5 | [35] | |
| 5 p.o. bait (6 months) | 109.9 CCID50 | 60 days | 0/5 | 0/5 | 0/5 | 5/5 |
p.o. = per os, D = day, p.f.u. = plaque forming units, CCID50 = cell culture infective dose 50%.