PMC full text:
Published online 2015 Mar 27. doi: 10.1289/ehp.1409004
Table 3
Relation of baseline water arsenic (N = 10,853) and baseline urinary creatinine-adjusted arsenic (N = 10,549) with adjusted annual changes in systolic blood pressure (SBP) over 7 years of follow-up.
| Baseline exposure | Range | Model 1 change/year (mmHg) | Model 2 change/year (mmHg) | Model 3 change/year (mmHg) |
|---|---|---|---|---|
| Water arsenic (μg/L) | ||||
| Q1 | < 12 | Reference | Reference | Reference |
| Q2 | 12–62 | 0.45 (0.32, 0.58) | 0.42 (0.29, 0.56) | 0.43 (0.29, 0.56) |
| Q3 | 62–148 | 0.60 (0.46, 0.73) | 0.55 (0.42, 0.68) | 0.54 (0.40, 0.67) |
| Q4 | > 148 | 0.51 (0.38, 0.65) | 0.48 (0.34, 0.61) | 0.48 (0.35, 0.61) |
| Urinary creatinine-adjusted arsenic (μg/g creatinine) | ||||
| Q1 | < 106 | Reference | Reference | Reference |
| Q2 | 106–199 | 0.40 (0.26, 0.53) | 0.38 (0.25, 0.52) | 0.39 (0.25, 0.52) |
| Q3 | 199–352 | 0.45 (0.32, 0.59) | 0.43 (0.30, 0.57) | 0.44 (0.30, 0.58) |
| Q4 | > 352 | 0.45 (0.31, 0.58) | 0.41 (0.27, 0.54) | 0.43 (0.29, 0.56) |
| Abbreviations: Q1, quartile 1; Q2, quartile 2; Q3, quartile 3; Q4, quartile 4. Model 1: controlled for baseline age and sex. Model 2: controlled for model 1 covariates plus BMI, smoking status, educational status, and history of diabetes. Model 3: controlled for model 2 covariates plus change of urinary creatinine-adjusted arsenic since baseline. | ||||