Co-LncRNA: investigating the lncRNA combinatorial effects in GO annotations and KEGG pathways based on human RNA-Seq data

Zheng Zhao; Jing Bai; Aiwei Wu; Yuan Wang; Jinwen Zhang; Zishan Wang; Yongsheng Li; Juan Xu; Xia Li

doi:10.1093/database/bav082

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Six main modules of Co-LncRNA. (a) The ‘CEGs’ module provides the co-expressed associations between the lncRNA and protein-coding genes. (b) The ‘CEGsFuncs’ module provides the combinatorial effects of the lncRNAs in the GO annotations and KEGG pathways. (c) The ‘merge CEGsFuncs’ module provides the integrated results for the combinatorial effects of lncRNAs in multiple datasets. (d) In the ‘CEGsNet’ module, the relevant networks that were built with lncRNAs and CEGs can be visualized. (e) In the ‘Analyse your data’ module, the users can submit their own matched lncRNA and protein-coding gene expression profiles to investigate the combinatorial effects among the lncRNAs. (f) All of the internal lncRNA and protein-coding gene expression data and the lncRNA-CEG pairs can be downloaded in the ‘Download’ module for further analyses.