Lysosomal recruitment of TSC2 is a universal response to cellular stress

Constantinos Demetriades; Monika Plescher; Aurelio A. Teleman

doi:10.1038/ncomms10662

Figure 7

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Recruitment of TSC2 to lysosomes is a universal feature of inhibitory stimuli towards mTORC1 inactivation.

Schematic model depicting the relationship between various stimuli that inhibit mTORC1 and their effect on lysosomal relocalization of TSC2. Each individual stress or starvation condition alone is sufficient to induce recruitment of TSC2 to lysosomes and thereby to inhibit mTORC1. Only when all stresses are absent is TSC2 cytoplasmic. The integration of all inhibitory stimuli on TSC2 ensures that mTORC1 will be inactivated in all situations, where conditions are not optimal and therefore do not favour growth.