Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure

Kenneth C. Bedi, Jr.; Nathaniel W Snyder; Jeffrey Brandimarto; Moez Aziz; Clementina Mesaros; Andrew J. Worth; Linda L. Wang; Ali Javaheri; Ian A. Blair; Kenneth Margulies; J. Eduardo Rame

doi:10.1161/CIRCULATIONAHA.115.017545

Figure 3

An external file that holds a picture, illustration, etc.
Object name is nihms751757f3a.jpg

An external file that holds a picture, illustration, etc.
Object name is nihms751757f3b.jpg

Acyl-CoA quantitation by SID-LC-MS/MS analysis demonstrates metabolic alterations. (A) The ratio of succinyl-CoA/acetyl-CoA is significantly decreased in failing myocardium (B) A significant change in failing hearts of short chain acyl-CoA species, including the ketogenic 3-hydroxybutanoyl-CoA (β-HB), is observed as compared to non-failing. A Mann-Whitney non-parametric test performed for each of these comparisons.