Figure 3

Actin cytoskeleton and insulin-stimulated GLUT4 translocation control in adipocytes. In adipocytes, cytosolic and cortical actin organization is involved in GLUT4 storing vesicle (GSV) transport by insulin stimulation. When adipocytes are hypertrophied, enlarged unilocular lipid droplets and expanded cell volume may impede cortical actin dynamics, resulting in improper/deficient translocation of GSVs. This indicates the importance of the adipocyte cytoskeleton in the regulation of adipocyte glucose metabolism in response to insulin.