PMC full text:
Published online 2016 Apr 28. doi: 10.4254/wjh.v8.i12.557
Table 2
Drug | Embryotoxicity and/or teratogenicity1 | Dose-escalation2 | Transfer across placenta | Transfer into milk | FDA Pregnancy Category3 | |
Sofosbuvir | No | 28-fold | Yes | Yes | B | |
Simeprevir | Yes | 4-fold | Yes | Yes | C | |
Daclatasvir | Yes | 4-fold | Yes | Yes | NA4 | |
Ledipasvir | No | Maternal toxic doses | Yes | Yes | B | |
Viekirax | Ombitasvir | Yes | 4-fold | Minimal | Yes | B |
Paritaprevir | 32-fold | |||||
Ritonavir | 8-fold | |||||
Dasabuvir | No | 48-fold | Minimal | Yes | B |
1Based on animal studies;
2Dose escalation above therapeutic dose;
3FDA Pregnancy Category without association with ribavirin. NA: Not available; FDA: The Food and Drug Administration.