Figure 3

(a) ATAC-seq profiles in skeletal muscle replicates and combined compared with similar profiles in adipose²¹ and the lymphoblastoid cell line GM12878 (ref. ²⁰), and to reference chromatin state maps in diverse cell or tissue types. (b) Skeletal muscle combined replicate ATAC-seq peak calls show enrichment for skeletal muscle-active chromatin states, which is pronounced at TSS-distal regions. (c) Example ATAC-seq footprint aggregate plots at CTCF and MYOD sites. (d) Relative genome coverage by different classes of skeletal muscle regulatory elements. (e) Skeletal muscle cis-eQTL enrichments at different mESI bins relative to the regulatory elements described in d.