The Immune System’s Role in Sepsis Progression, Resolution and Long-Term Outcome

PMC full text:

Immunol Rev. Author manuscript; available in PMC 2017 Nov 1.

Published in final edited form as:

Immunol Rev. 2016 Nov; 274(1): 330–353.

Table 1

Immune Modulator	G-CSF	GM-CSF	IFNγ	PD-1 and PD-L1	IL-3	IL-7	IL-15

Cellular Benefit	Improve neutrophil and monocyte production and release	Improve neutrophil and monocyte production and function	Improve monocyte HLA-DR expression and function	Biomarker to identify candidates for immune modulatory therapy	Promote stem cell and progenitor development	Increase T cell proliferation and recruitment	Decrease NK, T cell, and NKT cell apoptosis
	Improve meylopoiesis and granulopoiesis	Enhance monocyte and lymphocyte cytotoxicity	Reduce infection and related complications	Reverse T cell exhaustion	Enhance lymphopoiesis in combination with IL-7	Decrease lymphocyte apoptosis	Increase NK, T cell, and NKT cell proliferation and activation
		Augment T cell responses	Improve immunity against fungal infections	Promote lymphocyte proliferation		Increase T cell IFNγ secretion
		Reduce nosocomial infection acquisition		Augment neutrophil and monocyte cytotoxicity		Improve T cell homing and pathogen clearance
		Reduce ventilator days		Reduce opportunistic infections		Increases T cell receptor diversity