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Published online 2017 Mar 7. doi: 10.1186/s12940-017-0231-7
Table 4
Associations of arsenic exposure and LINE-1 methylation levels with BP through multivariate regression analyses
| Independent variables | Dependent variable DBP | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All subjects | Males | Females | ||||||||||
| Model 1 | Model 2 | Model 1 | Model 2 | Model 1 | Model 2 | |||||||
| β (95% CI) | p-value | β (95% CI) | p-value | β (95% CI) | p-value | β (95% CI) | p-value | β (95% CI) | p-value | β (95% CI) | p-value | |
| Water As | 0.742 (0.189,1.294) | <0.01 | 0.608 (0.053,1.163) | <0.05 | 0.513 (−0.159,1.184) | 0.133 | 0.509 (−0.166,1.184) | 0.138 | 1.009 (0.078,1.941) | <0.05 | 0.614 (−0.324,1.551) | 0.197 |
| LINE-1 | −1.084 (−1.787,−0.382) | <0.01 | −0.944 (−1.652,−0.235) | <0.01 | −0.138 (−1.123,0.846) | 0.781 | −0.097 (−1.079,0.884) | 0.844 | −1.786 (−2.808,−0.765) | <0.01 | −1.591 (−2.652,−0.529) | <0.01 |
| Hair As | 1.324 (0.315,2.333) | <0.05 | 1.133 (0.129, 2.138) | <0.05 | 0.926 (−0.255,2.107) | 0.123 | 0.919 (−0.268,2.107) | 0.128 | 1.870 (0.097,3.643) | <0.05 | 1.301 (−0.444,3.046) | 0.142 |
| LINE-1 | −0.976 (−1.679,−0.272) | <0.01 | −0.097 (−1.078,0.884) | 0.845 | −1.625 (−2.664,−0.586) | <0.01 | ||||||
| Nail As | 1.972 (0.810,3.134) | <0.01 | 1.642 (0.458, 2.825) | <0.01 | 1.847 (0.357,3.338) | <0.05 | 1.850 (0.341,3.358) | <0.05 | 2.068 (0.240,3.897) | <0.05 | 1.209 (−0.656,3.074) | 0.202 |
| LINE-1 | −0.854 (−1.567,−0.141) | <0.05 | 0.012 (−0.962,0.985) | 0.981 | −1.567 (−2.640,0.493) | <0.01 | ||||||
| Dependent variable SBP | ||||||||||||
| Water As | 1.098 (0.257,1.939) | <0.05 | 0.888 (0.044,1.732) | <0.05 | 0.481 (−0.472,1.433) | 0.320 | 0.470 (−0.487,1.428) | 0.333 | 1.678 (0.213,3.143) | <0.05 | 1.140 (−0.350,2.630) | 0.132 |
| LINE-1 | −1.687 (−2.755,−0.619) | <0.01 | −1.481 (−2.559,− 0.403) | <0.01 | −0.308 (−1.696,1.080) | 0.661 | −0.270 (−1.661,1.120) | 0.701 | −2.527 (−4.155,−0.899) | <0.01 | −2.163 (−3.850,−0.476) | <0.05 |
| Hair As | 1.904 (0.367,3.441) | <0.05 | 1.603 (0.074, 3.133) | <0.05 | 1.257 (−0.410,2.925) | 0.138 | 1.241 (−0.435,2.916) | 0.145 | 2.562 (−0.248,5.371) | 0.074 | 1.753 (−1.037,4.543) | 0.216 |
| LINE-1 | −1.533 (−2.603,−0.426) | <0.01 | −0.252 (−1.636,1.132) | 0.719 | −2.309 (−3.970,−0.649) | <0.01 | ||||||
| Nail As | 2.930 (1.161,4.700) | <0.01 | 2.408 (0.608, 4.209) | <0.01 | 2.368 (0.257,4.480) | <0.05 | 2.345 (0.209,4.482) | <0.05 | 3.294 (0.412,6.176) | <0.05 | 2.119 (−0.849, 5.086) | 0.160 |
| LINE-1 | −1.349 (−2.433, 0.265) | <0.05 | −0.118 (−1.496,1.261) | 0.866 | −2.142 (−3.850,−0.434) | <0.05 | ||||||
Log-transformed values of arsenic concentrations were used. Before adjustment (Model 1) and after adjustment (Model 2) with LINE-1 methylation levels