Figure 2

(A) Each node represents a viral genome from RefSeq, with its shape representing the viral family (as indicated in the legend) and each distinct color the node’s viral cluster (VC). Edges between nodes indicate a statistically significant relationship between the protein profiles of their viral genomes, with edge colors (darker = more significant) corresponding to their weighted similarity scores (threshold of ≥1). VCs within the network are discriminated using the MCL algorithm (‘Materials and Methods’) and denoted as separate colors. The position of 26 heterogeneous VCs that contain 2 or more genera is indicated. (B) Precision and recall of network-based assignments as compared to ICTV assignments for each taxonomic level (genus, family, order, and type). (C) Percentage (Y-axis) of VCs that contain the number (X-axis) of each ICTV taxonomic level (genus, family, and order).