PMC full text:
Published online 2017 Jun 15. doi: 10.1186/s13287-017-0598-y
Table 1
Important components of SVF, respective sizes, and surface markers
| Cell types of the SVF | Cell size range [in µm]* | Molecular markers# [1, 26, 29] | |
|---|---|---|---|
| Positive | Negative | ||
| ADSC | ~10–25 μm and reported up to 200+ μm in culture [34–36] | CD34, CD73, CD13, CD90, CD105, CD29 | CD31, CD45, CD144 |
| EPC | ~7–8 μm (smallest defined) [37] | CD34, CD31, CD133, CD146 | CD45 |
| EC | ~10–30 μm [38] | CD31, FVIII | CD34 |
| T regulatory cells | ~7–12 μm [39, 40] | CD4, CD25, Foxp3, CD8 | – |
| Macrophages | ~20 μm [41] | CD45, CD14, CD34, CD206 | – |
| Smooth muscle cells | ~3–20 μm in width and 20–500 μm in length [42, 43] | Smooth muscle actin (SMA) | – |
| Pericytes | Up to ~70 μm in length [44] | CD146, CD90, CD73, CD44, CD29, CD13 | CD34, CD45, CD56 |
| Pre-adipocytes | ~10 μm [45] | CD34 | CD45, CD31, CD146 |
*Diameter; unless mentioned otherwise
The Table captures the approximate range of cell sizes as reported in different studies [34–45] and provides an overview of surface antigens for the respective cell type [1, 26, 29]. # Includes surface or CD markers, cytoplasmic and nuclear factors
ADSC adipose-derived stem/stromal cells, EC endothelial cells, EPC endothelial precursor cells, SVF stromal vascular fraction