UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction

Lawrence Kazak; Edward T. Chouchani; Irina G. Stavrovskaya; Gina Z. Lu; Mark P. Jedrychowski; Daniel F. Egan; Manju Kumari; Xingxing Kong; Brian K. Erickson; John Szpyt; Evan D. Rosen; Michael P. Murphy; Bruce S. Kristal; Steven P. Gygi; Bruce M. Spiegelman

doi:10.1073/pnas.1705406114

Fig. S2.

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The role of cyclosporine A in UCP1-KO BAT mitochondrial calcium buffering capacity. Ca²⁺ and TMRM monitoring of UCP1-KO BAT mitochondria respiring on pyruvate/malate.