Figure 1

Serological and histological findings of NDMA‐induced liver injury in WT and MMP‐13 KO mice. (A and B) Serum levels of aspartate transaminase (AST) and alanine transaminase (ALT) in WT and MMP‐13 KO mice treated with or without NDMA. The data are mean ± S.D. of eight animals. ***P < 0.001 NDMA‐treated mice versus untreated control mice; ^# P < 0.001 NDMA‐treated WT versus MMP‐13 KO mice. (C–F) Haematoxylin and eosin staining of liver tissues from WT and MMP‐13 KO mice without NDMA treatment (C and D) and with NDMA treatment (E and F). Note that the marked contrast of hepatic necrosis with haemorrhage and inflammatory cell infiltration in NDMA‐treated WT and MMP‐13 KO mouse livers shown in E and F, respectively. Original magnification, ×100 for C, D, and E; ×40 for F.