Arsenic Methylation Capacity and Metabolic Syndrome in the 2013–2014 U.S. National Health and Nutrition Examination Survey (NHANES)

Clare Pace; Julie Smith-Gagen; Jeff Angermann

doi:10.3390/ijerph15010168

Table 6

Binary logistic regression; DV: Metabolic syndrome in women, fully adjusted model ^a.

IV	Normal BMI ^b			Overweight BMI ^c			Obese BMI ^d
IV	R²	OR [95% CI]	p-Value ^e	R²	OR [95% CI]	p-Value	R²	OR [95% CI]	p-Value
%iAs ^f	0.145	0.955 [0.854, 1.069]	0.426	0.179	1.026 [0.950, 1.109]	0.509	0.050	0.992 [0.942, 1.044]	0.746
%MMA ^g	0.182	0.826 [0.701, 0.973]	0.022 *	0.219	1.113 [1.016, 1.218]	0.021 *	0.057	0.966 [0.919, 1.015]	0.174
%DMA ^h	0.167	1.085 [0.999, 1.178]	0.053	0.203	0.951 [0.903 1.003]	0.063	0.054	1.018 [0.986 1.052]	0.273
PMI ⁱ	0.160	0.644 [0.365, 1.135]	0.128	0.187	1.149 [0.912, 1.446]	0.239	0.049	0.992 [0.879 1.120]	0.896
SMI ^j	0.175	11.485 [1.371, 96.196]	0.024 *	0.220	0.089 [0.011, 0.704]	0.022 *	0.064	2.590 [0.926, 7.243]	0.070

^a adjusted for age (continuous), Poverty Income Ratio (PIR < 1 vs. PIR ≥ 1)—calculated by dividing family income by the poverty guidelines specific to the survey year [30], race (White vs. non-White), and smoking status (dichotomous); ^b BMI < 25.0; ^c 25.0 ≤ BMI < 30.0; ^d BMI ≥ 30.0, R² represents Cox & Snell R² value; ^e p-value obtained from binary logistic regression (* significant at (α = 0.05)); ^f urine % arsenite; ^g urine % monomethylarsonous and monomethylarsonic acid; ^h urine % dimethylarsinic and dimethylarsinous acid; ⁱ primary methylation index; ^j secondary methylation index.