PMC full text:
Environ Res. Author manuscript; available in PMC 2018 Dec 3.
Published in final edited form as:
Environ Res. 2018 Nov; 167: 248–254.
Published online 2018 Jul 27. doi: 10.1016/j.envres.2018.07.022Table 2.
Diabetes odds ratios for tertiles of various metrics of arsenic water concentrations
| Arsenic metric | Arsenic level | Diabetes | Unadjusted OR (95% CI) | Adjusted* OR (95% CI) | |
|---|---|---|---|---|---|
| Yes | No | ||||
| Cumulative exposure: 0 year lag (µg/L-years) | 0–2416 | 70 | 281 | 1.00 (Ref) | 1.00 (Ref) |
| 2417–8664 | 74 | 276 | 1.08 (0.75–1.55) | 1.14 (0.78–1.66) | |
| ≥8665 | 90 | 262 | 1.38 (0.97–1.97) | 1.50 (1.03–2.19) | |
| p-trend | 0.06 | 0.03 | |||
| Cumulative exposure: 40 year lag (µg/L-years) | 0–609 | 70 | 276 | 1.00 (Ref) | 1.00 (Ref) |
| 610–5279 | 68 | 278 | 0.96 (0.66–1.40) | 0.97 (0.66–1.43) | |
| ≥5280 | 93 | 254 | 1.44 (1.01–2.06) | 1.53 (1.05–2.23) | |
| p-trend | 0.016 | 0.009 | |||
| Highest year exposure: 0 year lag (µg/L) | 0–60 | 85 | 326 | 1.00 (Ref) | 1.00 (Ref) |
| 61–635 | 68 | 222 | 1.17 (0.82–1.69) | 1.28 (0.88–1.85) | |
| ≥636 | 81 | 271 | 1.15 (0.81–1.62) | 1.28 (0.89–1.84) | |
| p-trend | 0.63 | 0.25 | |||
| Highest year exposure: 40 year lag (µg/L) | 0–60 | 102 | 364 | 1.00 (Ref) | 1.00 (Ref) |
| 61–286 | 49 | 176 | 0.99 (0.68–1.46) | 1.04 (0.70–1.55) | |
| ≥287 | 80 | 268 | 1.07 (0.76–1.49) | 1.16 (0.82–1.64) | |
| p-trend | 0.69 | 0.39 | |||
| Average lifetime exposure: 0 year lag (µg/L) | 0–38 | 74 | 276 | 1.00 (Ref) | 1.00 (Ref) |
| 39–129 | 72 | 279 | 0.96 (0.67–1.39) | 1.02 (0.70–1.48) | |
| ≥130 | 88 | 264 | 1.24 (0.87–1.77) | 1.43 (0.98–2.07) | |
| p-trend | 0.16 | 0.04 | |||
| Average exposure: 40 year lag (µg/L) | 0–22 | 73 | 273 | 1.00 (Ref) | 1.00 (Ref) |
| 23–222 | 74 | 272 | 1.02 (0.71–1.46) | 0.99 (0.68–1.44) | |
| ≥223 | 84 | 263 | 1.19 (0.84–1.71) | 1.36 (0.93–1.97) | |
| p-trend | 0.28 | 0.07 | |||
Abbreviations: CI, confidence interval; OR, odds ratio; Ref, reference group
*Adjusted for age (<60, 60–70, >70 years old), sex, BMI (<25, 25–30, ≥30 kg/m2), cancer status, smoking (never-smokers, >0 to <10, ≥10 cigarettes/day)