Figure 5
F8-VEGF-C improves lymphatic clearance function.
(A) In vivo imaging system (IVIS) images showing tracked signal decay of intradermally injected, exclusively lymphatic-drained near-infrared dye P20D800 in ears of inflamed K14-VEGF-A–transgenic mice that received either PBS or F8-VEGF-C. (B) Quantification of clearance rate of P20D800 of inflamed ear skin. (C) Quantification of half-life of P20D800 in inflamed ear skin (n = 5 animals per group, 2-tailed Student’s t test, 1 of 2 similar experiments shown). Data represent mean ± SD. *P < 0.05.