Figure 1.

MERS-CoV and S protein structures and vaccine targets in MERS-CoV S protein. (A) Schematic structure of MERS-CoV and its key structural proteins, including S, N, M, and E proteins. (B) Schematic structure of MERS-CoV S protein and its functional regions. S protein is composed of S1 and S2 subunits. NTD, N-terminal domain. RBD, receptor-binding domain. RBM, receptor-binding motif. FP, fusion peptide. HR1 and HR2, heptad repeat 1 and 2 regions. TM, transmembrane. CP, cytoplasmic tail. (C) Key vaccine targets in MERS-CoV S protein and its fragments.