Long noncoding RNAs are involved in multiple immunological pathways in response to vaccination

Diógenes S. de Lima; Lucas E. Cardozo; Vinicius Maracaja-Coutinho; Andreas Suhrbier; Karim Mane; David Jeffries; Eduardo L. V. Silveira; Paulo P. Amaral; Rino Rappuoli; Thushan I. de Silva; Helder I. Nakaya

doi:10.1073/pnas.1822046116

Fig. 3.

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FAM30A expression correlates to antibody production and to gene segments within the IgH locus. (A) Correlations between FAM30A and antibody titers with corresponding 95% confidence interval (x-axis) are plotted for each cohort (y-axis). Red vertical line and shaded region represent the correlation summary and its 95% confidence interval, respectively. (B) FAM30A expression is higher in B cells according to ref. 28. (C) Fold-change correlation between FAM30A and gene segments within the IgH locus at day 7 after inactivated IV. Each circle represents Pearson correlation coefficient in different IV cohorts. Meta-analysis P values are represented below cohort identifiers.