Hyaluronic acid-curcumin conjugate suppresses the fibrotic functions of myofibroblasts from contractive joint by the PTGER2 demethylation

Dongjie Yu; Ze Zhuang; Jianhua Ren; Xuefeng Hu; Zhe Wang; Jieyu Zhang; Yuansen Luo; Kun Wang; Ronghan He; Yunbing Wang

doi:10.1093/rb/rbz016

Figure 4

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The mRNA and protein expressions of PTGER2 and α-SMA (n = 3). (A) The mRNA expressions were measured by RT-qPCR. (B) The protein expressions were assayed by immunoblotting, with mean densitometry relative to β-actin shown in graphs underneath the representative blot. Control group: cells were treated neither TGF-β nor HA-Cur; fibrosis group: cells treated with TGF-β; HA-Cur group: cells treated with both TGF-β and HA-Cur. *P < 0.05 relative to the control group. **P < 0.05 relative to fibrosis group.