PMC full text:
Published online 2019 Oct 14. doi: 10.1002/14651858.CD009027.pub3
Summary of findings 2
Six to 12 months AED treatment compared with 24 months AED treatment for seizure control in neurocysticercosis
| Six to 12 months AED treatment compared with 24 months AED treatment for seizure control in people with neurocysticercosis | ||||||
| Patient or population: people with neurocysticercosis Settings: outpatients, in India Intervention: 6 to 12 months AED treatment Comparison: 24 months AED treatment | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Certainty of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| 24 months AED treatment | 6 to 12 months AED treatment | |||||
| Seizure control Seizure recurrence Follow‐up: 18 months | Study population | OR 1.36 (95% CI 0.72 to 2.57) | 385 (3 studies) | ⊕⊕⊝⊝ low1,2 | OR > 1 indicates seizure recurrence is more likely on 6 to 12 months AED treatment | |
| 103 per 1000 | 140 per 1000 (74 to 264 per 1000) | |||||
| Assumed Risk: The event rate in the long duration AEDs group multiplied by 1000. The event rate is the proportion of the total, in which the event occurred. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; OR: Odds ratio; | ||||||
| GRADE Working Group grades of evidence High certainty: Further research is very unlikely to change our confidence in the estimate of effect. Moderate certainty: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low certainty: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low certainty: We are very uncertain about the estimate. | ||||||
1 Down‐graded twice due to lack of blinding of participants and researchers in all the included studies, unclear risk of bias in patient concealment, and lack of applicability.
2 Inconsistency in report of withdrawals and reasons for them