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Published online 2004 Feb 22. doi: 10.1038/nm1001
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Antiviral activity of pegylated IFN-α against SCV in vitro and its biological activity in macaques.

(a) Effect of pegylated IFN-α against SCV infection in vitro. Similar results were obtained in three separate experiments. (b) Pharmacokinetic analysis of pegylated IFN-α (b) and induction of neopterin (c) in macaques treated with PBS (□, control group; n = 4) or pegylated IFN-α (▪, prophylactic group; n = 4) on days −3 and −1. Data are expressed as mean ± s.d. **, P < 0.01 compared with control.

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