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Published online 2020 Jun 15. doi: 10.1007/s00204-020-02733-2
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Fig. 6

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Dose–response relation of N7-GA-Gua adducts in rat kidney orally exposed to 0.1–10,000 μg AA/kg bw (R2 = 0.99) (only kidney shown in the linear-log plot for graphic clarity). Insert, linear–linear plot of the low dose range (0.1–1000 μg AA/kg bw); shaded, range of DNA background of N7-carboxyethyl-dGua in human liver (see also part A "Fundamental considerations", chapter “background DNA lesions”). Values represent mean values ± SDs (n = 8 or n = 3). Reprinted with permission from (Watzek et al. 2012), Copyright (2012) American Chemical Society

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