PMC full text:
Published online 2020 Jun 15. doi: 10.1007/s00204-020-02733-2
Table 10
Clastogenicity and mutagenicity of selected PAs (based on Allemang et al. 2018; Chen et al. 2010b; EFSA 2011a).
Agent | MN in vitro | MN in vivo | CA in vitro | CA in vivo | SCE in vitro | Mutations in bacteria | Mutations in Drosophila |
---|---|---|---|---|---|---|---|
Heliotrine | + | + | + | + | ± | + | |
Isatidine | + | ± | – | ||||
Integerrimine | + | + | + | ||||
Lasiocarpine | + | + | + | ||||
Monocrotaline | + | + | + | + | – | + | |
Retrorsine | + | + | + | + | |||
Riddelliine | + | ± | + | + | ± | ||
Senecionine | – | + | |||||
Seneciphylline | + | + | ( +) | + | |||
Senkirkine | + | + | + | + |
MN micronuclei, CA chromosomal aberrations, SCE sister chromatid exchange. “ + ” positive result, “ – ” negative result, empty cells not tested