Figure 7.

The strategy description targeting the different sites involved in the SARS/GRP78 interaction. Chemical molecules have been extracted from compound libraries (PubChem and SATPdb). Screening of these molecules (100 polyphenols and 40 peptides) was carried out by the docking method by AutoDock Vina and ClusPro server. This method offers a precise and efficient anchoring tool, which is based on empirical notation functions. It is based on the average binding energy scores in AutoDock Vina,⁴³ and the root-mean-square deviation (RMSD) in ClusPro to generate clusters with the most probable models of the complex. Selection of structures based on energy minimization. GRP78 indicates glucose-regulating protein 78.