PMC full text:
Published online 2020 Oct 21. doi: 10.1177/1177932220965505
Table 2.
Recapitulating table details the size and bonds types of different residues between the targets (SARS-CoV-2 peak, GRP78) and the peptides (satpdb18674, satpdb18446, and satpdb12488, satpdb14438, and satpdb28899).
| Peptide | Target | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction residues Peptides-GRP78 | Interaction residues Peptides-Spike | ||||||||
| Peptide | GRP78 | Interaction size (A) | interaction Types | Peptide | Spike | Interaction size (A) | interaction Types | ||
| Region III | Region IV | ||||||||
| Satpdb12488 | ASP-19 | THR-434 | 2; 1.8; 2.6 | O-NH; OH-O; O-O | MET-5 | TYR-473 | – | 1.8; | OH-O |
| THR-2 | VAL-429 | 2.5 | NH-O | PHE-4 | TYR-473 | 3.2 | OH-O | ||
| ASP-16 | LYS-447 | 1.8; 2.7 | NH-O. N-O | THR-13 | TYR-453 | 2.8 | OH-O | ||
| ALA-17 | LY-447 | 3.4 | NH-NH | ASP-16 | TYR-453 | 3.8 | OH-O | ||
| MET-5 | SER-452 | 1.8, 2.6 | OH-O; O-O | THR-13 | ARG-403 | 2.2 | NH-O | ||
| 2.3, 3.9 | NH-O; O-O | THR-2 | ALA-475 | 3.4 | O-O | ||||
| PHE-4 | SER-452 | 2.3 | NH-O | THR-3 | ALA-475 | 3.7 | O-O | ||
| TYR-15 | TYR-505 | 3.6 | OH-O | ||||||
| GLU-10 | LYS-417 | 3.0 | O-NH | ||||||
| Satpdb14438 | ILE-13 | THR-434 | 1.9 | OH-O | – | – | – | – | – |
| 2.9 | O-O | ||||||||
| SER-12 | VAL-429 | 1.9; 2.9 | NH-O; O-O | ||||||
| THR-9 | THR-458 | 2.2; 3.1; 3.3 | NH-O; N-N;O-O | ||||||
| Satpdb18446 | TYR-3 | THR-434 | 3.4 | O-OH | – | – | – | – | – |
| ASN-4 | VAL-429 | 1.9; 2.8 | NH-O; O-N | ||||||
| TYR-3 | GLN-449 | 2.6; 1.9; 3.6 | NH-OH: NH-O | ||||||
| N-OH | |||||||||
| VAL-1 | SER-452 | 3.9 | NH-NH | ||||||
| THR-10 | SER-452 | 1.9; 2.8 | O-OH; O-O | ||||||
| Satpdb18674 | GLN-1 | VAL-429 | 2.5; 2.5; 2.9 | NH-NH; 2H-N | SER-4 | – | PRO-479 | 1.9; 2.8 | OH-O; O-O |
| SER-4 | GLN-449 | 2.1; 2.8 | NH-O; N-O | PHE-5 | PRO-479 | 3.6 | NH-O | ||
| THR-7 | SER-452 | 3.2 | NH-O | SER-4 | CYS-480 | 3.8 | O-NH | ||
| SER-4 | ASN-481 | 3.5 | OH-O | ||||||
| TYR-2 | ASN-481 | 2.0; 3 | NH-O; O-N | ||||||
| PHE-5 | PHE-486 | 2.9 | NH-O | ||||||
| Satpdb28899 | ASP-20 | VAL-429 | 3.9 | O-O | ARG-1 | GLU-484 | – | 2.2; 2.8; 3.4 | NH-N; 2NH-O |
| LEU-19 | VAL-429 | 2.9; 3.4 | NH-O; O-N | ASP-20 | ARG-466 | 1.7; 2-6; | NH-O; N-O | ||
| SER-16 | THR-458 | 1.8; 2.6 | OH-O; O-O | LEU-19 | ARG-466 | 3.6 | NH-O | ||
| THR-15 | THR-458 | 3.6 | NH-O | GLU-17 | TYR-351 | 2.1; 3 | OH-O; O-O | ||
| THR-15 | TYR-351 | 3.7 | OH-O | ||||||
| GLU-17 | SER-349 | 2.9 | OH-O | ||||||
| SER-16 | ARG-346 | 2.0; 2.6 | NH-O; N-O | ||||||
Abbreviations: GRP78, glucose-regulating protein 78; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.