Targeted Disruption of Mouse Yin Yang 1 Transcription Factor Results in Peri-Implantation Lethality

Mary E. Donohoe; Xiaolin Zhang; Lynda McGinnis; John Biggers; En Li; Yang Shi

doi:10.1128/mcb.19.10.7237

FIG. 4

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YY1 has a widespread expression pattern in the developing embryo. Whole-mount in situ hybridization of E7.5 (A), E8.5 (B), E9.5 (C), and E12.5 (D) wild-type embryos with a YY1 antisense riboprobe. Hybridization of an E12.5 embryo with a YY1 sense riboprobe was included as a negative control (E). The Brachyury (T) riboprobe was used as a positive control (5a).