Contribution of trace element exposure to gestational diabetes mellitus through disturbing the gut microbiome

Yuqing Zhang; Ting Chen; Yiyun Zhang; Qi Hu; Xu Wang; Hang Chang; Jian-Hua Mao; Antoine M. Snijders; Yankai Xia

doi:10.1016/j.envint.2021.106520

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Correlations between serum trace element exposure and gut microbiome composition.

(A) Linear regression of per unit increase of trace elements and alpha diversity indices. Models were adjusted for maternal age, parity, pre-pregnant BMI and educational levels. (B) Spearman correlation of trace elements exposure and relative abundance of GDM-related CAGs. (C) Mediating effects of alpha-diversity, CAG2 and CAG7 on GDM by rubidium (Rb) and antimony (Sb). * indicates P-value <0.05.