Rutaecarpine Promotes Adipose Thermogenesis and Protects against HFD-Induced Obesity via AMPK/PGC-1α Pathway

Dandan Chen; Yanan Duan; Shuxiang Yu; Xinwen Zhang; Ni Li; Jingya Li

doi:10.3390/ph15040469

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Graphical abstract. In this study, we revealed the effects of rutaecarpine (Rut) on thermogeneis and weight management. Rut can reduce adiposity, improve insulin resistance and increase respiratory activity in mice with HFD-induced obesity. The mechanism of the effects of Rut involved AMPK/PGC-1α pathway, and we demonstrated that AMPK deficiency in adipose tissue suppressed the upregulation of thermogenic markers and beneficial metabolic effects in Rut-treated mice.