Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat

Josef Oeckl; Petra Janovska; Katerina Adamcova; Kristina Bardova; Sarah Brunner; Sebastian Dieckmann; Josef Ecker; Tobias Fromme; Jiri Funda; Thomas Gantert; Piero Giansanti; Maria Soledad Hidrobo; Ondrej Kuda; Bernhard Kuster; Yongguo Li; Radek Pohl; Sabine Schmitt; Sabine Schweizer; Hans Zischka; Petr Zouhar; Jan Kopecky; Martin Klingenspor

doi:10.1016/j.molmet.2022.101499

Figure 7

Expression of selected genes in iBAT of C57BL/6J wild type (WT) and UCP1-knockout (UCP1KO) mice acclimated to different ambient temperatures: 30 °C “warm-acclimated” (WA), 20 °C “mild cold-acclimated” (MCA), or 6 °C “cold-acclimated” (CA), for at least three weeks. n = 4–5 animals (data from one experiment; confirmed in two independent experiments). “a” indicates a significant difference from the WA group of the respective genotype. “b” indicates a significant difference from the MCA group of the respective genotype. “c” indicates a significant difference between the two genotypes within one treatment level. Abbreviations of genes: CD36 molecule (Cd36), diacylglycerol O-acyltransferase 1 (Dgat1), diacylglycerol O-acyltransferase 2 (Dgat2), glycerol kinase (Gk), glycerol-3-phosphate dehydrogenase 1 (Gpd1), lipoprotein lipase (Lpl).