Multi-marker approach using C-reactive protein, procalcitonin, neutrophil CD64 index for the prognosis of sepsis in intensive care unit: a retrospective cohort study

Table 3

The discriminating capability of biomarkers in predicting 28-day mortality of septic patients

Variables

CRP

PCT

nCD64

PCT + nCD64

CRP + nCD64

AUC

0.798 (0.752 to 0.839)

NA

0.833 (0.790 to 0.871)

P = 0.289

0.906 (0.870 to 0.935)

P = 0.001

0.910 (0.875 to 0.938)

P < 0.001

0.916 (0.881 to 0.943)

P < 0.001

NRI

NA

− 0.953 (− 1.154 to − 0.157)

P = 0.010

0.182 (− 0.068 to 0.470)

P = 0.143

0.572 (0.031 to 1.102)

P = 0.038

1.137 (0.936 to 1.335)

P < 0.001

IDI

NA

− 0.134 (− 0.204 to 0.052)

P < 0.001

0.135 (0.048 to 0.226)

P < 0.001

0.136 (0.044 to 0.224)

P = 0.01

0.232 (0.157 to 0.306)

P < 0.001