SARS-CoV-2-Specific IgG and IgA response in maternal blood and breastmilk of vaccinated naïve and convalescent lactating participants

Yesica Longueira; Diego S. Ojeda; Rocio B. Antivero Battistelli; Lautaro Sanchez; Santiago Oviedo Rouco; Daniel Albano; Eleonora Guevara; Vanesa Valls; María A. Pando; Andrea V. Gamarnik

doi:10.3389/fimmu.2022.909995

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Longitudinal antibodies measurements in fully vaccinated breastfeeding without previous infection. IgG and IgA anti-spike antibody levels measured as geometric means by OD at 450 nm in naïve mothers receiving Sputnik V C1 and C2 vaccine (Gamaleya, N= 4), ChAdOx1-S vaccine (AstraZeneca, N= 12) and BBIBP10 CorV vaccine (Sinopharm, N=12). Samples were obtained as a function of time at 44 (T1) and 120 (T2) days after second doses of Sputnik V, ChAdOx1‐S and BIBP-CorV vaccines. Cut-off for serum and breast milk samples resulted from the mean of OD450 values from negative controls plus 3 times the standard deviation and is shown as dotted line. Wilcoxon matched-pair test was used. Statistical significance is shown with the following notations: ****, P < 0.0001; ***, P < 0.001; *, P < 0.05; ns, not significant.