Hypoxia modeling techniques: A review

Nataliya Salyha; Iryna Oliynyk

doi:10.1016/j.heliyon.2023.e13238

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Heliyon. 2023 Feb; 9(2): e13238.

Published online 2023 Jan 26. doi: 10.1016/j.heliyon.2023.e13238

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Table 1

Critical ascent height and lifetime at critical height of Sprague-Dawley and Wistar rats in simulation of hypobaric hypoxia.

Hypobaric characteristics	Sprague-Dowley	Wistar
Critical altitude lethal altitude	9250–10668 m altitude [[49], [50], [51], [52], [53]]	9754–11500 m altitude [[57], [58], [59], [60]]
High tolerance^a to hypoxia rats (HHT)	More than 20 min [52,[54], [55], [56]]	More than 25 min [57]
Medium (normal) tolerance^a to hypoxia rats (HHN)	10–20 min [52,56]	10–25 min [57]
Low tolerance^a to hypoxia rats (hypobaric hypoxia Susceptible-HHS)	Less than 10 min [55,56]	Less than 10 min [57]

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^aThe differences in basic tolerance to oxygen deficiency. Animals are divided into tolerant- and susceptible to hypoxia groups (low, medium, high) in a decompression chamber at extreme altitudes.