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Volume 102(12);  2005 Mar 22

In This Issue

This Week in PNAS
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4217–4218. doi: 10.1073/iti1205102
PMCID:
PMC555510
Article PDF–230K

Commentary

Understanding biology by reverse engineering the control
Claire J. Tomlin, Jeffrey D. Axelrod
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4219–4220. Published online 2005 Mar 14. doi: 10.1073/pnas.0500276102
PMCID:
PMC555517
Article PDF–128K

Physical Sciences

Applied Mathematics

Subnets of scale-free networks are not scale-free: Sampling properties of networks
Michael P. H. Stumpf, Carsten Wiuf, Robert M. May
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4221–4224. Published online 2005 Mar 14. doi: 10.1073/pnas.0501179102
PMCID:
PMC555505
Abstract Article PDF–270K

Physics

Reversible self-assembly and directed assembly of DNA-linked micrometer-sized colloids
Marie-Pierre Valignat, Olivier Theodoly, John C. Crocker, William B. Russel, Paul M. Chaikin
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4225–4229. Published online 2005 Mar 9. doi: 10.1073/pnas.0500507102
PMCID:
PMC553286
Abstract Article PDF–542K
Simulation of dynamical properties of normal and superfluid helium
Akira Nakayama, Nancy Makri
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4230–4234. Published online 2005 Mar 7. doi: 10.1073/pnas.0501127102
PMCID:
PMC555495
Abstract Article PDF–575K

Statistics

On the utility of pooling biological samples in microarray experiments
C. Kendziorski, R. A. Irizarry, K.-S. Chen, J. D. Haag, M. N. Gould
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4252–4257. Published online 2005 Mar 8. doi: 10.1073/pnas.0500607102
PMCID:
PMC552978
Abstract Article PDF–572K

Biological Sciences

Biochemistry

Biosynthesis of a D-amino acid in peptide linkage by an enzyme from frog skin secretions
Alexander Jilek, Christa Mollay, Christa Tippelt, Jacques Grassi, Giuseppina Mignogna, Johannes Müllegger, Veronika Sander, Christine Fehrer, Donatella Barra, Günther Kreil
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4235–4239. Published online 2005 Mar 9. doi: 10.1073/pnas.0500789102
PMCID:
PMC555527
Abstract Article PDF–413K
The 1.51-Å structure of the poxvirus L1 protein, a target of potent neutralizing antibodies
Hua-Poo Su, Scott C. Garman, Timothy J. Allison, Christiana Fogg, Bernard Moss, David N. Garboczi
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4240–4245. Published online 2005 Mar 10. doi: 10.1073/pnas.0501103102
PMCID:
PMC555483
Abstract Article PDF–600K
Target-directed proteolysis at the ribosome
Tanja Henrichs, Natasha Mikhaleva, Charlotte Conz, Elke Deuerling, Dana Boyd, Adrian Zelazny, Eitan Bibi, Nenad Ban, Michael Ehrmann
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4246–4251. doi: 10.1073/pnas.0408520102
PMCID:
PMC555484
Abstract Article PDF–368K
Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast
Qinshan Gao, Biswadip Das, Fred Sherman, Lynne E. Maquat
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4258–4263. Published online 2005 Mar 7. doi: 10.1073/pnas.0500684102
PMCID:
PMC555522
Abstract Article PDF–542K
From cyclohydrolase to oxidoreductase: Discovery of nitrile reductase activity in a common fold
Steven G. Van Lanen, John S. Reader, Manal A. Swairjo, Valérie de Crécy-Lagard, Bobby Lee, Dirk Iwata-Reuyl
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4264–4269. Published online 2005 Mar 14. doi: 10.1073/pnas.0408056102
PMCID:
PMC555470
Abstract Article PDF–608K
Lack of heme synthesis in a free-living eukaryote
Anita U. Rao, Lynn K. Carta, Emmanuel Lesuisse, Iqbal Hamza
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4270–4275. Published online 2005 Mar 14. doi: 10.1073/pnas.0500877102
PMCID:
PMC555530
Abstract Article PDF–425K
Intramolecular interaction between phosphorylated tyrosine-783 and the C-terminal Src homology 2 domain activates phospholipase C-γ1
Benoit Poulin, Fujio Sekiya, Sue Goo Rhee
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4276–4281. Published online 2005 Mar 11. doi: 10.1073/pnas.0409590102
PMCID:
PMC555506
Abstract Article PDF–464K

Biophysics

Local conformational fluctuations can modulate the coupling between proton binding and global structural transitions in proteins
Steven T. Whitten, Bertrand García-Moreno E., Vincent J. Hilser
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4282–4287. Published online 2005 Mar 14. doi: 10.1073/pnas.0407499102
PMCID:
PMC555489
Abstract Article PDF–538K
Activation of pausing F1 motor by external force
Yoko Hirono-Hara, Koji Ishizuka, Kazuhiko Kinosita, Jr., Masasuke Yoshida, Hiroyuki Noji
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4288–4293. Published online 2005 Mar 9. doi: 10.1073/pnas.0406486102
PMCID:
PMC555477
Abstract Article PDF–575K
Structural characterization of copper(II) binding to α-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease
Rodolfo M. Rasia, Carlos W. Bertoncini, Derek Marsh, Wolfgang Hoyer, Dmitry Cherny, Markus Zweckstetter, Christian Griesinger, Thomas M. Jovin, Claudio O. Fernández
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4294–4299. Published online 2005 Mar 14. doi: 10.1073/pnas.0407881102
PMCID:
PMC555498
Abstract Article PDF–417K

Cell Biology

FRET measurements of cell-traction forces and nano-scale clustering of adhesion ligands varied by substrate stiffness
Hyun Joon Kong, Thomas R. Polte, Eben Alsberg, David J. Mooney
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4300–4305. Published online 2005 Mar 14. doi: 10.1073/pnas.0405873102
PMCID:
PMC555469
Abstract Article PDF–633K
ROMK1 channel activity is regulated by monoubiquitination
Dao-Hong Lin, Hyacinth Sterling, Zhijian Wang, Elisa Babilonia, Baofeng Yang, Ke Dong, Steven C. Hebert, Gerhard Giebisch, Wen-Hui Wang
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4306–4311. Published online 2005 Mar 14. doi: 10.1073/pnas.0409767102
PMCID:
PMC555508
Abstract Article PDF–482K
PTEN as an effector in the signaling of antimigratory G protein-coupled receptor
Teresa Sanchez, Shobha Thangada, Ming-Tao Wu, Christopher D. Kontos, Dianqing Wu, Hong Wu, Timothy Hla
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4312–4317. Published online 2005 Mar 11. doi: 10.1073/pnas.0409784102
PMCID:
PMC555509
Abstract Article PDF–464K
A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs
Jeffrey J. Tung, David V. Hansen, Kenneth H. Ban, Alexander V. Loktev, Matthew K. Summers, John R. Adler, III, Peter K. Jackson
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4318–4323. Published online 2005 Mar 7. doi: 10.1073/pnas.0501108102
PMCID:
PMC552977
Abstract Article PDF–571K
MET and MYC cooperate in mammary tumorigenesis
Alana L. Welm, Suwon Kim, Bryan E. Welm, J. Michael Bishop
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4324–4329. Published online 2005 Feb 28. doi: 10.1073/pnas.0500470102
PMCID:
PMC552784
Abstract Article PDF–875K
The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation
Barrington G. Burnett, Randall N. Pittman
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4330–4335. Published online 2005 Mar 14. doi: 10.1073/pnas.0407252102
PMCID:
PMC555481
Abstract Article PDF–477K
A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells
Ann M. Winter-Vann, Rudi A. Baron, Waihay Wong, June dela Cruz, John D. York, David M. Gooden, Martin O. Bergo, Stephen G. Young, Eric J. Toone, Patrick J. Casey
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4336–4341. doi: 10.1073/pnas.0408107102
PMCID:
PMC555472
Abstract Article PDF–472K
Disease-associated mutations cause premature oligomerization of myelin proteolipid protein in the endoplasmic reticulum
Eileithyia Swanton, Andrew Holland, Stephen High, Philip Woodman
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4342–4347. Published online 2005 Mar 7. doi: 10.1073/pnas.0407287102
PMCID:
PMC555485
Abstract Article PDF–430K
Engineering of vault nanocapsules with enzymatic and fluorescent properties
Valerie A. Kickhoefer, Yvette Garcia, Yeshi Mikyas, Erik Johansson, Jing C. Zhou, Sujna Raval-Fernandes, Payam Minoofar, Jeffrey I. Zink, Bruce Dunn, Phoebe L. Stewart, Leonard H. Rome
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4348–4352. Published online 2005 Mar 7. doi: 10.1073/pnas.0500929102
PMCID:
PMC555531
Abstract Article PDF–537K
Force production by depolymerizing microtubules: A theoretical study
M. I. Molodtsov, E. L. Grishchuk, A. K. Efremov, J. R. McIntosh, F. I. Ataullakhanov
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4353–4358. Published online 2005 Mar 14. doi: 10.1073/pnas.0501142102
PMCID:
PMC555502
Abstract Article PDF–361K
Syne proteins anchor muscle nuclei at the neuromuscular junction
R. Mark Grady, Daniel A. Starr, Gail L. Ackerman, Joshua R. Sanes, Min Han
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4359–4364. Published online 2005 Mar 4. doi: 10.1073/pnas.0500711102
PMCID:
PMC555524
Abstract Article PDF–710K
Colonic tumorigenesis in BubR1+/–ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability
Chinthalapally V. Rao, Yang-Ming Yang, Malisetty V. Swamy, Tongyi Liu, Yuqiang Fang, Radma Mahmood, Meena Jhanwar-Uniyal, Wei Dai
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4365–4370. Published online 2005 Mar 14. doi: 10.1073/pnas.0407822102
PMCID:
PMC555497
Abstract Article PDF–670K

Developmental Biology

Tbx2b is essential for neuronal differentiation along the dorsal/ventral axis of the zebrafish retina
Jeffrey M. Gross, John E. Dowling
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4371–4376. Published online 2005 Mar 8. doi: 10.1073/pnas.0501061102
PMCID:
PMC555474
Abstract Article PDF–805K
The basic helix–loop–helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord
Alida Filippi, Natascia Tiso, Gianluca Deflorian, Elisabetta Zecchin, Marino Bortolussi, Francesco Argenton
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4377–4382. Published online 2005 Feb 24. doi: 10.1073/pnas.0407284102
PMCID:
PMC549604
Abstract Article PDF–790K

Ecology

Remote analysis of biological invasion and biogeochemical change
Gregory P. Asner, Peter M. Vitousek
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4383–4386. Published online 2005 Mar 10. doi: 10.1073/pnas.0500823102
PMCID:
PMC554001
Abstract Article PDF–488K
Functional- and abundance-based mechanisms explain diversity loss due to N fertilization
Katharine N. Suding, Scott L. Collins, Laura Gough, Christopher Clark, Elsa E. Cleland, Katherine L. Gross, Daniel G. Milchunas, Steven Pennings
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4387–4392. Published online 2005 Mar 8. doi: 10.1073/pnas.0408648102
PMCID:
PMC555488
Abstract Article PDF–438K
Phytoplankton species richness scales consistently from laboratory microcosms to the world's oceans
Val H. Smith, Bryan L. Foster, James P. Grover, Robert D. Holt, Mathew A. Leibold, Frank deNoyelles, Jr.
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4393–4396. Published online 2005 Mar 7. doi: 10.1073/pnas.0500094102
PMCID:
PMC555514
Abstract Article PDF–197K

Environmental Sciences

Climate-driven regime shifts in the biological communities of arctic lakes
John P. Smol, Alexander P. Wolfe, H. John B. Birks, Marianne S. V. Douglas, Vivienne J. Jones, Atte Korhola, Reinhard Pienitz, Kathleen Rühland, Sanna Sorvari, Dermot Antoniades, Stephen J. Brooks, Marie-Andrée Fallu, Mike Hughes, Bronwyn E. Keatley, Tamsin E. Laing, Neal Michelutti, Larisa Nazarova, Marjut Nyman, Andrew M. Paterson, Bianca Perren, Roberto Quinlan, Milla Rautio, Émilie Saulnier-Talbot, Susanna Siitonen, Nadia Solovieva, Jan Weckström
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4397–4402. Published online 2005 Feb 28. doi: 10.1073/pnas.0500245102
PMCID:
PMC555516
Abstract Article PDF–619K

Evolution

Resolution of a deep animal divergence by the pattern of intron conservation
Scott William Roy, Walter Gilbert
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4403–4408. Published online 2005 Mar 15. doi: 10.1073/pnas.0409891102
PMCID:
PMC555513
Abstract Article PDF–573K
Osteocalcin protein sequences of Neanderthals and modern primates
Christina M. Nielsen-Marsh, Michael P. Richards, Peter V. Hauschka, Jane E. Thomas-Oates, Erik Trinkaus, Paul B. Pettitt, Ivor Karavanić, Hendrik Poinar, Matthew J. Collins
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4409–4413. Published online 2005 Mar 7. doi: 10.1073/pnas.0500450102
PMCID:
PMC555519
Abstract Article PDF–406K
Mate choice decisions of stickleback females predictably modified by MHC peptide ligands
Manfred Milinski, Siân Griffiths, K. Mathias Wegner, Thorsten B. H. Reusch, Annette Haas-Assenbaum, Thomas Boehm
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4414–4418. Published online 2005 Mar 8. doi: 10.1073/pnas.0408264102
PMCID:
PMC555479
Abstract Article PDF–310K
Integrons in Xanthomonas: A source of species genome diversity
Michael R. Gillings, Marita P. Holley, H. W. Stokes, Andrew J. Holmes
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4419–4424. Published online 2005 Mar 8. doi: 10.1073/pnas.0406620102
PMCID:
PMC555480
Abstract Article PDF–463K
Genetic analysis reveals the complex structure of HIV-1 transmission within defined risk groups
Stéphane Hué, Deenan Pillay, Jonathan P. Clewley, Oliver G. Pybus
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4425–4429. Published online 2005 Mar 14. doi: 10.1073/pnas.0407534102
PMCID:
PMC555492
Abstract Article PDF–385K
Spliceosomal introns in the deep-branching eukaryote Trichomonas vaginalis
Štěpánka Vaňáčová, Weihong Yan, Jane M. Carlton, Patricia J. Johnson
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4430–4435. Published online 2005 Mar 11. doi: 10.1073/pnas.0407500102
PMCID:
PMC554003
Abstract Article PDF–406K
Incorporating gene-specific variation when inferring and evaluating optimal evolutionary tree topologies from multilocus sequence data
Tae-Kun Seo, Hirohisa Kishino, Jeffrey L. Thorne
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4436–4441. Published online 2005 Mar 11. doi: 10.1073/pnas.0408313102
PMCID:
PMC555482
Abstract Article PDF–268K
A mechanism for the association of amino acids with their codons and the origin of the genetic code
Shelley D. Copley, Eric Smith, Harold J. Morowitz
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4442–4447. Published online 2005 Mar 11. doi: 10.1073/pnas.0501049102
PMCID:
PMC555468
Abstract Article PDF–479K
Suppression of viral infectivity through lethal defection
Ana Grande-Pérez, Ester Lázaro, Pedro Lowenstein, Esteban Domingo, Susanna C. Manrubia
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4448–4452. Published online 2005 Mar 14. doi: 10.1073/pnas.0408871102
PMCID:
PMC555496
Abstract Article PDF–318K

Genetics

Identification of transcribed sequences in Arabidopsis thaliana by using high-resolution genome tiling arrays
Viktor Stolc, Manoj Pratim Samanta, Waraporn Tongprasit, Himanshu Sethi, Shoudan Liang, David C. Nelson, Adrian Hegeman, Clark Nelson, David Rancour, Sebastian Bednarek, Eldon L. Ulrich, Qin Zhao, Russell L. Wrobel, Craig S. Newman, Brian G. Fox, George N. Phillips, Jr., John L. Markley, Michael R. Sussman
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4453–4458. Published online 2005 Mar 8. doi: 10.1073/pnas.0408203102
PMCID:
PMC555476
Abstract Article PDF–398K
Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues
Xinmin Zhang, Duncan T. Odom, Seung-Hoi Koo, Michael D. Conkright, Gianluca Canettieri, Jennifer Best, Huaming Chen, Richard Jenner, Elizabeth Herbolsheimer, Elizabeth Jacobsen, Shilpa Kadam, Joseph R. Ecker, Beverly Emerson, John B. Hogenesch, Terry Unterman, Richard A. Young, Marc Montminy
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4459–4464. Published online 2005 Mar 7. doi: 10.1073/pnas.0501076102
PMCID:
PMC555478
Abstract Article PDF–524K
On the role of Cro in λ prophage induction
Sine L. Svenningsen, Nina Costantino, Donald L. Court, Sankar Adhya
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4465–4469. Published online 2005 Feb 23. doi: 10.1073/pnas.0409839102
PMCID:
PMC555511
Abstract Article PDF–370K
Quantitative kinetic analysis of the bacteriophage λ genetic network
Oren Kobiler, Assaf Rokney, Nir Friedman, Donald L. Court, Joel Stavans, Amos B. Oppenheim
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4470–4475. Published online 2005 Feb 22. doi: 10.1073/pnas.0500670102
PMCID:
PMC549295
Abstract Article PDF–680K
Adaptive evolution in the SRZ chemoreceptor families of Caenorhabditis elegans and Caenorhabditis briggsae
James H. Thomas, Joanna L. Kelley, Hugh M. Robertson, Kim Ly, Willie J. Swanson
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4476–4481. Published online 2005 Mar 10. doi: 10.1073/pnas.0406469102
PMCID:
PMC555475
Abstract Article PDF–743K
Juxtaposition of C(2)M and the transverse filament protein C(3)G within the central region of Drosophila synaptonemal complex
Lorinda K. Anderson, Suzanne M. Royer, Scott L. Page, Kim S. McKim, Ann Lai, Mary A. Lilly, R. Scott Hawley
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4482–4487. Published online 2005 Mar 14. doi: 10.1073/pnas.0500172102
PMCID:
PMC555515
Abstract Article PDF–500K
The interaction between σ70 and the β-flap of Escherichia coli RNA polymerase inhibits extension of nascent RNA during early elongation
Bryce E. Nickels, Sean J. Garrity, Vladimir Mekler, Leonid Minakhin, Konstantin Severinov, Richard H. Ebright, Ann Hochschild
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4488–4493. Published online 2005 Mar 10. doi: 10.1073/pnas.0409850102
PMCID:
PMC555512
Abstract Article PDF–497K
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16
Seung Wook Oh, Arnab Mukhopadhyay, Nenad Svrzikapa, Feng Jiang, Roger J. Davis, Heidi A. Tissenbaum
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4494–4499. Published online 2005 Mar 14. doi: 10.1073/pnas.0500749102
PMCID:
PMC555525
Abstract Article PDF–433K
Segmental trisomy of chromosome 17: A mouse model of human aneuploidy syndromes
Tomáš Vacík, Michael Ort, Soňa Gregorová, Petr Strnad, Radek Blatný, Nathalie Conte, Allan Bradley, Jan Bureš, Jiří Forejt
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4500–4505. Published online 2005 Mar 8. doi: 10.1073/pnas.0500802102
PMCID:
PMC552979
Abstract Article PDF–424K

Immunology

A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression
Ai Kotani, Il-mi Okazaki, Masamichi Muramatsu, Kazuo Kinoshita, Nasim A. Begum, Toshiharu Nakajima, Hirohisa Saito, Tasuku Honjo
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4506–4511. Published online 2005 Mar 14. doi: 10.1073/pnas.0500830102
PMCID:
PMC555529
Abstract Article PDF–326K
Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection
Michael R. Betts, Barbara Exley, David A. Price, Anju Bansal, Zenaido Tres Camacho, Vanessa Teaberry, Sadie M. West, David R. Ambrozak, Georgia Tomaras, Mario Roederer, J. Michael Kilby, Jim Tartaglia, Robert Belshe, Feng Gao, Daniel C. Douek, Kent J. Weinhold, Richard A. Koup, Paul Goepfert, Guido Ferrari
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4512–4517. Published online 2005 Mar 7. doi: 10.1073/pnas.0408773102
PMCID:
PMC552973
Abstract Article PDF–655K
Long-term in vivo provision of antigen-specific T cell immunity by programming hematopoietic stem cells
Lili Yang, David Baltimore
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4518–4523. Published online 2005 Mar 9. doi: 10.1073/pnas.0500600102
PMCID:
PMC553287
Abstract Article PDF–661K
STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFβ-activated kinase 1 for STAT3 Ser-727 phosphorylation
Hirotada Kojima, Takanori Sasaki, Tohru Ishitani, Shun-ichiro Iemura, Hong Zhao, Shuhei Kaneko, Hiroyuki Kunimoto, Tohru Natsume, Kunihiro Matsumoto, Koichi Nakajima
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4524–4529. Published online 2005 Mar 11. doi: 10.1073/pnas.0500679102
PMCID:
PMC555521
Abstract Article PDF–503K
Multiple mechanisms allow Mycobacterium tuberculosis to continuously inhibit MHC class II-mediated antigen presentation by macrophages
Stewart T. Chang, Jennifer J. Linderman, Denise E. Kirschner
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4530–4535. Published online 2005 Mar 14. doi: 10.1073/pnas.0500362102
PMCID:
PMC555518
Abstract Article PDF–438K
A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1
Ning Zhang, Sadeet Inan, Alan Cowan, Ronghua Sun, Ji Ming Wang, Thomas J. Rogers, Michael Caterina, Joost J. Oppenheim
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4536–4541. Published online 2005 Mar 11. doi: 10.1073/pnas.0406030102
Correction in:
Proc Natl Acad Sci U S A. 2005 May 10; 102(19): 7050.
PMCID:
PMC555471
Abstract Article PDF–525K

Medical Sciences

A survey of homozygous deletions in human cancer genomes
Charles Cox, Graham Bignell, Chris Greenman, Arne Stabenau, William Warren, Philip Stephens, Helen Davies, Stephen Watt, Jon Teague, Sara Edkins, Ewan Birney, Douglas F. Easton, Richard Wooster, P. Andrew Futreal, Michael R. Stratton
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4542–4547. Published online 2005 Mar 10. doi: 10.1073/pnas.0408593102
PMCID:
PMC555487
Abstract Article PDF–383K
Inhibitors of type II NADH:menaquinone oxidoreductase represent a class of antitubercular drugs
Edward A. Weinstein, Takahiro Yano, Lin-Sheng Li, David Avarbock, Andrew Avarbock, Douglas Helm, Andrew A. McColm, Ken Duncan, John T. Lonsdale, Harvey Rubin
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4548–4553. Published online 2005 Mar 14. doi: 10.1073/pnas.0500469102
PMCID:
PMC555520
Abstract Article PDF–439K
Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development
Wilhelm Stoffel, Britta Jenke, Barbara Blöck, Markus Zumbansen, Jürgen Koebke
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4554–4559. Published online 2005 Mar 11. doi: 10.1073/pnas.0406380102
PMCID:
PMC555473
Abstract Article PDF–816K
Evidence for cross-genotype neutralization of hepatitis C virus pseudo-particles and enhancement of infectivity by apolipoprotein C1
Jean-Christophe Meunier, Ronald E. Engle, Kristina Faulk, Ming Zhao, Birke Bartosch, Harvey Alter, Suzanne U. Emerson, Francois-Loic Cosset, Robert H. Purcell, Jens Bukh
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4560–4565. Published online 2005 Mar 14. doi: 10.1073/pnas.0501275102
PMCID:
PMC555507
Abstract Article PDF–557K
High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma
Michael G. Anderson, Richard T. Libby, Douglas B. Gould, Richard S. Smith, Simon W. M. John
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4566–4571. Published online 2005 Mar 9. doi: 10.1073/pnas.0407357102
PMCID:
PMC555465
Abstract Article PDF–668K
Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells
Toshie Iwai, Takashi Kudo, Risa Kawamoto, Tomomi Kubota, Akira Togayachi, Toru Hiruma, Tomoko Okada, Toru Kawamoto, Kyoei Morozumi, Hisashi Narimatsu
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4572–4577. Published online 2005 Mar 8. doi: 10.1073/pnas.0407983102
PMCID:
PMC555466
Abstract Article PDF–648K
Effects of titanium particle size on osteoblast functions in vitro and in vivo
Moon G. Choi, Hae S. Koh, Daniel Kluess, Daniel O'Connor, Anshu Mathur, George A. Truskey, Janet Rubin, David X. F. Zhou, K.-L. Paul Sung
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4578–4583. Published online 2005 Mar 8. doi: 10.1073/pnas.0500693102
PMCID:
PMC555523
Abstract Article PDF–401K
Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress
Albena T. Dinkova-Kostova, Karen T. Liby, Katherine K. Stephenson, W. David Holtzclaw, Xiangqun Gao, Nanjoo Suh, Charlotte Williams, Renee Risingsong, Tadashi Honda, Gordon W. Gribble, Michael B. Sporn, Paul Talalay
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4584–4589. Published online 2005 Mar 14. doi: 10.1073/pnas.0500815102
PMCID:
PMC555528
Abstract Article PDF–528K

Microbiology

Viable adenovirus vaccine prototypes: High-level production of a papillomavirus capsid antigen from the major late transcriptional unit
Michael Berg, Julie DiFatta, Egbert Hoiczyk, Richard Schlegel, Gary Ketner
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4590–4595. Published online 2005 Mar 14. doi: 10.1073/pnas.0500933102
PMCID:
PMC554749
Abstract Article PDF–380K
Structures of two core subunits of the bacterial type IV secretion system, VirB8 from Brucella suis and ComB10 from Helicobacter pylori
Laurent Terradot, Richard Bayliss, Clasien Oomen, Gordon A. Leonard, Christian Baron, Gabriel Waksman
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4596–4601. Published online 2005 Mar 11. doi: 10.1073/pnas.0408927102
PMCID:
PMC555499
Abstract Article PDF–868K

Neuroscience

Coding for spatial goals in the prelimbic/infralimbic area of the rat frontal cortex
V. Hok, E. Save, P. P. Lenck-Santini, B. Poucet
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4602–4607. Published online 2005 Mar 10. doi: 10.1073/pnas.0407332102
PMCID:
PMC555486
Abstract Article PDF–430K
A previously uncharacterized role for estrogen receptor β: Defeminization of male brain and behavior
Andrea E. Kudwa, Cristian Bodo, Jan-Åke Gustafsson, Emilie F. Rissman
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4608–4612. Published online 2005 Mar 10. doi: 10.1073/pnas.0500752102
PMCID:
PMC555526
Abstract Article PDF–258K
Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion
Hailan Hu, Ming Li, Juan-Pablo Labrador, Jason McEwen, Eric C. Lai, Corey S. Goodman, Greg J. Bashaw
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4613–4618. Published online 2005 Mar 8. doi: 10.1073/pnas.0409325102
PMCID:
PMC555501
Abstract Article PDF–727K
Genotype–environment interactions in mouse behavior: A way out of the problem
Neri Kafkafi, Yoav Benjamini, Anat Sakov, Greg I. Elmer, Ilan Golani
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4619–4624. Published online 2005 Mar 11. doi: 10.1073/pnas.0409554102
PMCID:
PMC555503
Abstract Article PDF–460K
The RNA-binding protein HuD regulates neuronal cell identity and maturation
Wado Akamatsu, Hiroaki Fujihara, Takayuki Mitsuhashi, Masato Yano, Shinsuke Shibata, Yoshika Hayakawa, Hirotaka James Okano, Shin-ichi Sakakibara, Hiroshi Takano, Toshiya Takano, Takao Takahashi, Tetsuo Noda, Hideyuki Okano
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4625–4630. Published online 2005 Mar 11. doi: 10.1073/pnas.0407523102
PMCID:
PMC555491
Abstract Article PDF–532K
Activity-dependent maintenance and growth of dendrites in adult cortex
Chris Tailby, Layne L. Wright, Andrew B. Metha, Mike B. Calford
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4631–4636. Published online 2005 Mar 14. doi: 10.1073/pnas.0402747102
PMCID:
PMC555467
Abstract Article PDF–530K

Pharmacology

Role of Toll-like receptors 2 and 4 in the induction of cyclooxygenase-2 in vascular smooth muscle
Rosario Jimenez, Elizabeth Belcher, Shiranee Sriskandan, Ruth Lucas, Shaun McMaster, Ivana Vojnovic, Timothy D. Warner, Jane A. Mitchell
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4637–4642. Published online 2005 Mar 8. doi: 10.1073/pnas.0407655101
PMCID:
PMC555494
Abstract Article PDF–403K

Physiology

Receptor-induced depletion of phosphatidylinositol 4,5-bisphosphate inhibits inwardly rectifying K+ channels in a receptor-specific manner
Hana Cho, Doyun Lee, Suk Ho Lee, Won-Kyung Ho
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4643–4648. Published online 2005 Mar 14. doi: 10.1073/pnas.0408844102
PMCID:
PMC555493
Abstract Article PDF–440K

Plant Biology

Evidence that CRABS CLAW and TOUSLED have conserved their roles in carpel development since the ancestor of the extant angiosperms
Chloé Fourquin, Marion Vinauger-Douard, Bruno Fogliani, Christian Dumas, Charles P. Scutt
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4649–4654. Published online 2005 Mar 14. doi: 10.1073/pnas.0409577102
PMCID:
PMC555504
Abstract Article PDF–541K

Corrections

[No title available]
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4655. doi: 10.1073/pnas.0501116102
Corrects:
Proc Natl Acad Sci U S A. 2005 Jan 4; 102(1): 117–122.
PMCID:
PMC555490
Correction PDF–57K
[No title available]
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4655. doi: 10.1073/pnas.0501139102
Corrects:
Proc Natl Acad Sci U S A. 2004 Aug 3; 101(31): 11511–11516.
PMCID:
PMC555500
Correction PDF–57K
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