Volume 59(6); 2010 Jun

Perspectives in Diabetes

Islet Transplantation a Decade Later and Strategies for Filling a Half-Full Glass

R. Paul Robertson

Diabetes. 2010 Jun; 59(6): 1285–1291. doi: 10.2337/db09-1846

PMCID:: PMC2874688

Abstract Article PDF–645K

Original Articles

New Methodologies and Databases

Local Non-Esterified Fatty Acids Correlate With Inflammation in Atheroma Plaques of Patients With Type 2 Diabetes

Sebastián Mas, Roxana Martínez-Pinna, Jose Luis Martín-Ventura, Raul Pérez, Dulcenombre Gomez-Garre, Alberto Ortiz, Arturo Fernandez-Cruz, Fernando Vivanco, Jesús Egido

Diabetes. 2010 Jun; 59(6): 1292–1301. Published online 2010 Mar 3. doi: 10.2337/db09-0848

PMCID:: PMC2874689

Abstract Article PDF–995K

Metabolism

Molecular Characterization of Insulin-Mediated Suppression of Hepatic Glucose Production In Vivo

Christopher J. Ramnanan, Dale S. Edgerton, Noelia Rivera, Jose Irimia-Dominguez, Ben Farmer, Doss W. Neal, Margaret Lautz, E. Patrick Donahue, Catalina M. Meyer, Peter J. Roach, Alan D. Cherrington

Diabetes. 2010 Jun; 59(6): 1302–1311. Published online 2010 Feb 25. doi: 10.2337/db09-1625

PMCID:: PMC2874690

Abstract Article PDF–280K

PTEN Inhibition Improves Muscle Regeneration in Mice Fed a High-Fat Diet

Zhaoyong Hu, Huiling Wang, In Hee Lee, Swati Modi, Xiaonan Wang, Jie Du, William E. Mitch

Diabetes. 2010 Jun; 59(6): 1312–1320. Published online 2010 Mar 3. doi: 10.2337/db09-1155

PMCID:: PMC2874691

Abstract Article PDF–2.0M

Glycerol-3-Phosphate Acyltransferase 1 Deficiency in ob/ob Mice Diminishes Hepatic Steatosis but Does Not Protect Against Insulin Resistance or Obesity

Angela A. Wendel, Lei O. Li, Yue Li, Gary W. Cline, Gerald I. Shulman, Rosalind A. Coleman

Diabetes. 2010 Jun; 59(6): 1321–1329. Published online 2010 Mar 3. doi: 10.2337/db09-1380

PMCID:: PMC2874692

Abstract Article PDF–301K

Effect of Endogenous GLP-1 on Insulin Secretion in Type 2 Diabetes

Marzieh Salehi, Benedict Aulinger, Ronald L. Prigeon, David A. D'Alessio

Diabetes. 2010 Jun; 59(6): 1330–1337. Published online 2010 Mar 9. doi: 10.2337/db09-1253

PMCID:: PMC2874693

Abstract Article PDF–256K

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

Vanessa P. Houde, Sophie Brûlé, William T. Festuccia, Pierre-Gilles Blanchard, Kerstin Bellmann, Yves Deshaies, André Marette

Diabetes. 2010 Jun; 59(6): 1338–1348. Published online 2010 Mar 18. doi: 10.2337/db09-1324

PMCID:: PMC2874694

Abstract Article PDF–295K

Mechanisms of Insulin Resistance After Insulin-Induced Hypoglycemia in Humans: The Role of Lipolysis

Paola Lucidi, Paolo Rossetti, Francesca Porcellati, Simone Pampanelli, Paola Candeloro, Anna Marinelli Andreoli, Gabriele Perriello, Geremia B. Bolli, Carmine G. Fanelli

Diabetes. 2010 Jun; 59(6): 1349–1357. Published online 2010 Mar 18. doi: 10.2337/db09-0745

PMCID:: PMC2874695

Abstract Article PDF–315K

TBC1D1 Regulates Insulin- and Contraction-Induced Glucose Transport in Mouse Skeletal Muscle

Ding An, Taro Toyoda, Eric B. Taylor, Haiyan Yu, Nobuharu Fujii, Michael F. Hirshman, Laurie J. Goodyear

Diabetes. 2010 Jun; 59(6): 1358–1365. Published online 2010 Mar 18. doi: 10.2337/db09-1266

PMCID:: PMC2874696

Abstract Article PDF–158K

Alterations in Skeletal Muscle Fatty Acid Handling Predisposes Middle-Aged Mice to Diet-Induced Insulin Resistance

Debby P.Y. Koonen, Miranda M.Y. Sung, Cindy K.C. Kao, Vernon W. Dolinsky, Timothy R. Koves, Olga Ilkayeva, René L. Jacobs, Dennis E. Vance, Peter E. Light, Deborah M. Muoio, Maria Febbraio, Jason R.B. Dyck

Diabetes. 2010 Jun; 59(6): 1366–1375. Published online 2010 Mar 31. doi: 10.2337/db09-1142

PMCID:: PMC2874697

Abstract Article PDF–302K

Lipocalin-2 Deficiency Impairs Thermogenesis and Potentiates Diet-Induced Insulin Resistance in Mice

Hong Guo, Daozhong Jin, Yuanyuan Zhang, Wendy Wright, Merlijn Bazuine, David A. Brockman, David A. Bernlohr, Xiaoli Chen

Diabetes. 2010 Jun; 59(6): 1376–1385. Published online 2010 Mar 23. doi: 10.2337/db09-1735

PMCID:: PMC2874698

Abstract Article PDF–503K

Signal Transduction

Activation of AMP-Activated Protein Kinase Inhibits Oxidized LDL-Triggered Endoplasmic Reticulum Stress In Vivo

Yunzhou Dong, Miao Zhang, Shuangxi Wang, Bin Liang, Zhengxing Zhao, Chao Liu, Mingyuan Wu, Hyoung Chul Choi, Timothy J. Lyons, Ming-Hui Zou

Diabetes. 2010 Jun; 59(6): 1386–1396. Published online 2010 Mar 18. doi: 10.2337/db09-1637

Expression of Concern in:: Diabetes. 2023 Jul; 72(7): 1036.

PMCID:: PMC2874699

Abstract Article PDF–708K

Fat Cell–Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism

Anil Kumar, John C. Lawrence, Jr., Dae Young Jung, Hwi Jin Ko, Susanna R. Keller, Jason K. Kim, Mark A. Magnuson, Thurl E. Harris

Diabetes. 2010 Jun; 59(6): 1397–1406. Published online 2010 Mar 23. doi: 10.2337/db09-1061

PMCID:: PMC2874700

Abstract Article PDF–532K

Obesity Studies

Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α Overexpression Increases Lipid Oxidation in Myocytes From Extremely Obese Individuals

Leslie A. Consitt, Jill A. Bell, Timothy R. Koves, Deborah M. Muoio, Matthew W. Hulver, Kimberly R. Haynie, G. Lynis Dohm, Joseph A. Houmard

Diabetes. 2010 Jun; 59(6): 1407–1415. Published online 2010 Mar 3. doi: 10.2337/db09-1704

PMCID:: PMC2874701

Abstract Article PDF–338K

Critical Role of the Mesenteric Depot Versus Other Intra-abdominal Adipose Depots in the Development of Insulin Resistance in Young Rats

Karyn J. Catalano, Darko Stefanovski, Richard N. Bergman

Diabetes. 2010 Jun; 59(6): 1416–1423. Published online 2010 Mar 18. doi: 10.2337/db08-0675

PMCID:: PMC2874702

Abstract Article PDF–307K

Deletion of the α-Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity

William A. Chutkow, Andreas L. Birkenfeld, Jonathan D. Brown, Hui-Young Lee, David W. Frederick, Jun Yoshioka, Parth Patwari, Romy Kursawe, Samuel W. Cushman, Jorge Plutzky, Gerald I. Shulman, Varman T. Samuel, Richard T. Lee

Diabetes. 2010 Jun; 59(6): 1424–1434. Published online 2010 Mar 18. doi: 10.2337/db09-1212

PMCID:: PMC2874703

Abstract Article PDF–721K

Islet Studies

Ectopic Expression of E2F1 Stimulates β-Cell Proliferation and Function

Gael Grouwels, Ying Cai, Inge Hoebeke, Gunter Leuckx, Yves Heremans, Ulrike Ziebold, Geert Stangé, Marie Chintinne, Zhidong Ling, Daniel Pipeleers, Harry Heimberg, Mark Van de Casteele

Diabetes. 2010 Jun; 59(6): 1435–1444. Published online 2010 Mar 18. doi: 10.2337/db09-1295

PMCID:: PMC2874704

Abstract Article PDF–448K

Brief Report

Islet Studies

Physiologic and Pharmacologic Modulation of Glucose-Dependent Insulinotropic Polypeptide (GIP) Receptor Expression in β-Cells by Peroxisome Proliferator–Activated Receptor (PPAR)-γ Signaling: Possible Mechanism for the GIP Resistance in Type 2 Diabetes

Dhananjay Gupta, Mina Peshavaria, Navjot Monga, Thomas L. Jetton, Jack L. Leahy

Diabetes. 2010 Jun; 59(6): 1445–1450. Published online 2010 Mar 23. doi: 10.2337/db09-1655

PMCID:: PMC2874705

Abstract Article PDF–465K

Original Articles

Immunology and Transplantation

Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression

Timothy I.M. Tree, Jennifer Lawson, Hannah Edwards, Ania Skowera, Sefina Arif, Bart O. Roep, Mark Peakman

Diabetes. 2010 Jun; 59(6): 1451–1460. Published online 2010 Mar 18. doi: 10.2337/db09-0503

PMCID:: PMC2874706

Abstract Article PDF–468K

Prevention of Diabetes by FTY720-Mediated Stabilization of Peri-Islet Tertiary Lymphoid Organs

Cristina Penaranda, Qizhi Tang, Nancy H. Ruddle, Jeffrey A. Bluestone

Diabetes. 2010 Jun; 59(6): 1461–1468. Published online 2010 Mar 18. doi: 10.2337/db09-1129

PMCID:: PMC2874707

Abstract Article PDF–319K

Caspase Inhibitor Therapy Synergizes With Costimulation Blockade to Promote Indefinite Islet Allograft Survival

Juliet A. Emamaullee, Joy Davis, Rena Pawlick, Christian Toso, Shaheed Merani, Sui-Xiong Cai, Ben Tseng, A.M. James Shapiro

Diabetes. 2010 Jun; 59(6): 1469–1477. Published online 2010 Mar 23. doi: 10.2337/db09-0502

PMCID:: PMC2874708

Abstract Article PDF–497K

Idd9.2 and Idd9.3 Protective Alleles Function in CD4⁺ T-Cells and Nonlymphoid Cells to Prevent Expansion of Pathogenic Islet-Specific CD8⁺ T-Cells

Emma E. Hamilton-Williams, S.B. Justin Wong, Xavier Martinez, Daniel B. Rainbow, Kara M. Hunter, Linda S. Wicker, Linda A. Sherman

Diabetes. 2010 Jun; 59(6): 1478–1486. Published online 2010 Mar 18. doi: 10.2337/db09-1801

PMCID:: PMC2874709

Abstract Article PDF–384K

Pathophysiology

Platelet Tissue Factor Synthesis in Type 2 Diabetic Patients Is Resistant to Inhibition by Insulin

Anja J. Gerrits, Cornelis A. Koekman, Timon W. van Haeften, Jan Willem N. Akkerman

Diabetes. 2010 Jun; 59(6): 1487–1495. Published online 2010 Mar 3. doi: 10.2337/db09-1008

PMCID:: PMC2874710

Abstract Article PDF–236K

High-Mobility Group Box-1 Protein Promotes Angiogenesis After Peripheral Ischemia in Diabetic Mice Through a VEGF-Dependent Mechanism

Federico Biscetti, Giuseppe Straface, Raimondo De Cristofaro, Stefano Lancellotti, Paola Rizzo, Vincenzo Arena, Egidio Stigliano, Giovanni Pecorini, Kensuke Egashira, Giulia De Angelis, Giovanni Ghirlanda, Andrea Flex

Diabetes. 2010 Jun; 59(6): 1496–1505. Published online 2010 Mar 3. doi: 10.2337/db09-1507

PMCID:: PMC2874711

Abstract Article PDF–1.1M

Brief Report

Pathophysiology

Extracellular Fatty Acid Synthase: A Possible Surrogate Biomarker of Insulin Resistance

Jose Manuel Fernandez-Real, Javier A. Menendez, Jose Maria Moreno-Navarrete, Matthias Blüher, Alejandro Vazquez-Martin, María Jesús Vázquez, Francisco Ortega, Carlos Diéguez, Gema Frühbeck, Wifredo Ricart, Antonio Vidal-Puig

Diabetes. 2010 Jun; 59(6): 1506–1511. Published online 2010 Mar 18. doi: 10.2337/db09-1756

PMCID:: PMC2874712

Abstract Article PDF–294K

Original Articles

Complications

Cardiac-Specific IGF-1 Receptor Transgenic Expression Protects Against Cardiac Fibrosis and Diastolic Dysfunction in a Mouse Model of Diabetic Cardiomyopathy

Karina Huynh, Julie R. McMullen, Tracey L. Julius, Joon Win Tan, Jane E. Love, Nelly Cemerlang, Helen Kiriazis, Xiao-Jun Du, Rebecca H. Ritchie

Diabetes. 2010 Jun; 59(6): 1512–1520. Published online 2010 Mar 9. doi: 10.2337/db09-1456

PMCID:: PMC2874713

Abstract Article PDF–315K

Influence of Insulin in the Ventromedial Hypothalamus on Pancreatic Glucagon Secretion In Vivo

Sachin A. Paranjape, Owen Chan, Wanling Zhu, Adam M. Horblitt, Ewan C. McNay, James A. Cresswell, Jonathan S. Bogan, Rory J. McCrimmon, Robert S. Sherwin

Diabetes. 2010 Jun; 59(6): 1521–1527. Published online 2010 Mar 18. doi: 10.2337/db10-0014

PMCID:: PMC2874714

Abstract Article PDF–248K

Inhibition of Reactive Oxygen Species by Lovastatin Downregulates Vascular Endothelial Growth Factor Expression and Ameliorates Blood-Retinal Barrier Breakdown in db/db Mice: Role of NADPH Oxidase 4

Jingming Li, Joshua J. Wang, Qiang Yu, Kai Chen, Kalyankar Mahadev, Sarah X. Zhang

Diabetes. 2010 Jun; 59(6): 1528–1538. Published online 2010 Mar 23. doi: 10.2337/db09-1057

PMCID:: PMC2874715

Abstract Article PDF–659K

Genetics

MTNR1B G24E Variant Associates With BMI and Fasting Plasma Glucose in the General Population in Studies of 22,142 Europeans

Ehm A. Andersson, Birgitte Holst, Thomas Sparsø, Niels Grarup, Karina Banasik, Johan Holmkvist, Torben Jørgensen, Knut Borch-Johnsen, Kristoffer L. Egerod, Torsten Lauritzen, Thorkild I.A. Sørensen, Amélie Bonnefond, David Meyre, Philippe Froguel, Thue W. Schwartz, Oluf Pedersen, Torben Hansen

Diabetes. 2010 Jun; 59(6): 1539–1548. Published online 2010 Mar 3. doi: 10.2337/db09-1757

PMCID:: PMC2874716

Abstract Article PDF–196K

Brief Reports

Genetics

FTO Genetic Variation and Association With Obesity in West Africans and African Americans

Adebowale Adeyemo, Guanjie Chen, Jie Zhou, Daniel Shriner, Ayo Doumatey, Hanxia Huang, Charles Rotimi

Diabetes. 2010 Jun; 59(6): 1549–1554. Published online 2010 Mar 18. doi: 10.2337/db09-1252

PMCID:: PMC2874717

Abstract Article PDF–4.9M

Association Between CNDP1 Genotype and Diabetic Nephropathy Is Sex Specific

Antien L. Mooyaart, Ana Zutinic, Stephan J.L. Bakker, Diana C. Grootendorst, Nanne Kleefstra, Irene G.M. van Valkengoed, Stefan Böhringer, Henk J.G. Bilo, Friedo W. Dekker, Jan Anthonie Bruijn, Gerjan Navis, Bart Janssen, Hans J. Baelde, Emile De Heer

Diabetes. 2010 Jun; 59(6): 1555–1559. Published online 2010 Mar 23. doi: 10.2337/db09-1377

PMCID:: PMC2874718

Abstract Article PDF–93K

Articles from Diabetes are provided here courtesy of American Diabetes Association