Volume 288(16); 2013 Apr 19

Minireview

Human Genetic Disorders Caused by Mutations in Genes Encoding Biosynthetic Enzymes for Sulfated Glycosaminoglycans

Shuji Mizumoto, Shiro Ikegawa, Kazuyuki Sugahara

J Biol Chem. 2013 Apr 19; 288(16): 10953–10961. Published online 2013 Mar 1. doi: 10.1074/jbc.R112.437038

PMCID:: PMC3630846

Reports

Experimental Cerebral Malaria Develops Independently of Endothelial Expression of Intercellular Adhesion Molecule-1 (ICAM-1)

Theresa N. Ramos, Daniel C. Bullard, Meghan M. Darley, Kristin McDonald, David F. Crawford, Scott R. Barnum

J Biol Chem. 2013 Apr 19; 288(16): 10962–10966. Published online 2013 Mar 14. doi: 10.1074/jbc.C113.457028

PMCID:: PMC3630868

Abstract Article PDF–1.2M

Identification of GPR99 Protein as a Potential Third Cysteinyl Leukotriene Receptor with a Preference for Leukotriene E₄ Ligand

Yoshihide Kanaoka, Akiko Maekawa, K. Frank Austen

J Biol Chem. 2013 Apr 19; 288(16): 10967–10972. Published online 2013 Mar 15. doi: 10.1074/jbc.C113.453704

PMCID:: PMC3630866

Abstract Article PDF–778K

Cell Biology

The Overexpression of Hypomethylated miR-663 Induces Chemotherapy Resistance in Human Breast Cancer Cells by Targeting Heparin Sulfate Proteoglycan 2 (HSPG2)

Haiyan Hu, Shuqin Li, Xiuying Cui, Xiaobin Lv, Yu Jiao, Fengyan Yu, Herui Yao, Erwei Song, Yongsong Chen, Minghui Wang, Ling Lin

J Biol Chem. 2013 Apr 19; 288(16): 10973–10985. Published online 2013 Feb 22. doi: 10.1074/jbc.M112.434340

PMCID:: PMC3630848

Abstract Article PDF–4.9M

A Nitric Oxide-dependent Cross-talk between Class I and III Histone Deacetylases Accelerates Skin Repair

Francesco Spallotta, Chiara Cencioni, Stefania Straino, Simona Nanni, Jessica Rosati, Simona Artuso, Isabella Manni, Claudia Colussi, Giulia Piaggio, Fabio Martelli, Sergio Valente, Antonello Mai, Maurizio C. Capogrossi, Antonella Farsetti, Carlo Gaetano

J Biol Chem. 2013 Apr 19; 288(16): 11004–11012. Published online 2013 Mar 5. doi: 10.1074/jbc.M112.441816

PMCID:: PMC3630901

Abstract Article PDF–2.1M

miR-155 Regulates Immune Modulatory Properties of Mesenchymal Stem Cells by Targeting TAK1-binding Protein 2

Chunliang Xu, Guangwen Ren, Gang Cao, Qing Chen, Peishun Shou, Chunxing Zheng, Liming Du, Xiaoyan Han, Menghui Jiang, Qian Yang, Liangyu Lin, Guan Wang, Pengfei Yu, Xin Zhang, Wei Cao, Gary Brewer, Ying Wang, Yufang Shi

J Biol Chem. 2013 Apr 19; 288(16): 11074–11079. Published online 2013 Feb 28. doi: 10.1074/jbc.M112.414862

PMCID:: PMC3630877

Abstract Article PDF–1.3M

Notch Transcriptional Control of Vascular Smooth Muscle Regulatory Gene Expression and Function

Sanchita Basu, Dinesh Kumar Srinivasan, Ke Yang, Hema Raina, Suhanti Banerjee, Rongli Zhang, Steven A. Fisher, Aaron Proweller

J Biol Chem. 2013 Apr 19; 288(16): 11191–11202. Published online 2013 Mar 12. doi: 10.1074/jbc.M112.442996

PMCID:: PMC3630855

Abstract Article PDF–2.0M

Loss of Vacuolar H⁺-ATPase (V-ATPase) Activity in Yeast Generates an Iron Deprivation Signal That Is Moderated by Induction of the Peroxiredoxin TSA2

Heba I. Diab, Patricia M. Kane

J Biol Chem. 2013 Apr 19; 288(16): 11366–11377. Published online 2013 Mar 1. doi: 10.1074/jbc.M112.419259

PMCID:: PMC3630902

Abstract Article PDF–1.5M

Deletion of Autophagy-related 5 (Atg5) and Pik3c3 Genes in the Lens Causes Cataract Independent of Programmed Organelle Degradation

Hideaki Morishita, Satoshi Eguchi, Hirotaka Kimura, Junko Sasaki, Yuriko Sakamaki, Michael L. Robinson, Takehiko Sasaki, Noboru Mizushima

J Biol Chem. 2013 Apr 19; 288(16): 11436–11447. Published online 2013 Mar 11. doi: 10.1074/jbc.M112.437103

PMCID:: PMC3630873

Abstract Article PDF–6.8M

Deleterious Cholesterol Hydroperoxide Trafficking in Steroidogenic Acute Regulatory (StAR) Protein-expressing MA-10 Leydig Cells: IMPLICATIONS FOR OXIDATIVE STRESS-IMPAIRED STEROIDOGENESIS

Witold Korytowski, Anna Pilat, Jared C. Schmitt, Albert W. Girotti

J Biol Chem. 2013 Apr 19; 288(16): 11509–11519. Published online 2013 Mar 6. doi: 10.1074/jbc.M113.452151

PMCID:: PMC3630865

Abstract Article PDF–1016K

The Sec7 Guanine Nucleotide Exchange Factor GBF1 Regulates Membrane Recruitment of BIG1 and BIG2 Guanine Nucleotide Exchange Factors to the Trans-Golgi Network (TGN)

Jason Lowery, Tomasz Szul, Melanie Styers, Zoe Holloway, Viola Oorschot, Judith Klumperman, Elizabeth Sztul

J Biol Chem. 2013 Apr 19; 288(16): 11532–11545. Published online 2013 Feb 5. doi: 10.1074/jbc.M112.438481

PMCID:: PMC3630886

Abstract Article PDF–2.8M

Keratin 8 and 18 Loss in Epithelial Cancer Cells Increases Collective Cell Migration and Cisplatin Sensitivity through Claudin1 Up-regulation

Anne-Marie Fortier, Eric Asselin, Monique Cadrin

J Biol Chem. 2013 Apr 19; 288(16): 11555–11571. Published online 2013 Feb 28. doi: 10.1074/jbc.M112.428920

PMCID:: PMC3630871

Abstract Article PDF–5.6M

Tumor-suppressive Maspin Functions as a Reactive Oxygen Species Scavenger: IMPORTANCE OF CYSTEINE RESIDUES

Nitin Mahajan, Heidi Y. Shi, Thomas J. Lukas, Ming Zhang

J Biol Chem. 2013 Apr 19; 288(16): 11611–11620. Published online 2013 Mar 7. doi: 10.1074/jbc.M112.410852

PMCID:: PMC3630891

Abstract Article PDF–1.3M

DNA and Chromosomes

RIF1 Counteracts BRCA1-mediated End Resection during DNA Repair

Lin Feng, Ka-Wing Fong, Jiadong Wang, Wenqi Wang, Junjie Chen

J Biol Chem. 2013 Apr 19; 288(16): 11135–11143. Published online 2013 Mar 13. doi: 10.1074/jbc.M113.457440

PMCID:: PMC3630874

Abstract Article PDF–2.3M

Processing of DNA Double-stranded Breaks and Intermediates of Recombination and Repair by Saccharomyces cerevisiae Mre11 and Its Stimulation by Rad50, Xrs2, and Sae2 Proteins

Indrajeet Ghodke, K. Muniyappa

J Biol Chem. 2013 Apr 19; 288(16): 11273–11286. Published online 2013 Feb 27. doi: 10.1074/jbc.M112.439315

PMCID:: PMC3630844

Abstract Article PDF–3.5M

Enzymology

Substrate Placement Influences Reactivity in Non-heme Fe(II) Halogenases and Hydroxylases

Heather J. Kulik, Catherine L. Drennan

J Biol Chem. 2013 Apr 19; 288(16): 11233–11241. Published online 2013 Feb 28. doi: 10.1074/jbc.M112.415570

PMCID:: PMC3630895

Abstract Article PDF–1.6M

Chloroquine Binding Reveals Flavin Redox Switch Function of Quinone Reductase 2

Kevin K. K. Leung, Brian H. Shilton

J Biol Chem. 2013 Apr 19; 288(16): 11242–11251. Published online 2013 Mar 7. doi: 10.1074/jbc.M113.457002

PMCID:: PMC3630856

Abstract Article PDF–2.3M

Mycobacterium tuberculosis MutT1 (Rv2985) and ADPRase (Rv1700) Proteins Constitute a Two-stage Mechanism of 8-Oxo-dGTP and 8-Oxo-GTP Detoxification and Adenosine to Cytidine Mutation Avoidance

Aravind Goud G. Patil, Pau Biak Sang, Ashwin Govindan, Umesh Varshney

J Biol Chem. 2013 Apr 19; 288(16): 11252–11262. Published online 2013 Mar 5. doi: 10.1074/jbc.M112.442566

PMCID:: PMC3630869

Abstract Article PDF–2.0M

Multilevel Regulation of 2-Cys Peroxiredoxin Reaction Cycle by S-Nitrosylation

Rotem Engelman, Pnina Weisman-Shomer, Tamar Ziv, Jianqiang Xu, Elias S. J. Arnér, Moran Benhar

J Biol Chem. 2013 Apr 19; 288(16): 11312–11324. Published online 2013 Mar 11. doi: 10.1074/jbc.M112.433755

PMCID:: PMC3630883

Abstract Article PDF–2.8M

Single-molecule Investigation of Substrate Binding Kinetics and Protein Conformational Dynamics of a B-family Replicative DNA Polymerase

Brian A. Maxwell, Zucai Suo

J Biol Chem. 2013 Apr 19; 288(16): 11590–11600. Published online 2013 Mar 5. doi: 10.1074/jbc.M113.459982

PMCID:: PMC3630881

Abstract Article PDF–2.2M

Autoactivation of Thrombin Precursors

Nicola Pozzi, Zhiwei Chen, Fatima Zapata, Weiling Niu, Sergio Barranco-Medina, Leslie A. Pelc, Enrico Di Cera

J Biol Chem. 2013 Apr 19; 288(16): 11601–11610. Published online 2013 Mar 6. doi: 10.1074/jbc.M113.451542

PMCID:: PMC3630838

Abstract Article PDF–1.8M

Gene Regulation

The ETS Domain Transcription Factor ELK1 Directs a Critical Component of Growth Signaling by the Androgen Receptor in Prostate Cancer Cells

Mugdha Patki, Venkatesh Chari, Suneethi Sivakumaran, Mesfin Gonit, Robert Trumbly, Manohar Ratnam

J Biol Chem. 2013 Apr 19; 288(16): 11047–11065. Published online 2013 Feb 20. doi: 10.1074/jbc.M112.438473

PMCID:: PMC3630885

Abstract Article PDF–6.8M

Poly(ADP-ribose) Polymerase 1 Is a Key Regulator of Estrogen Receptor α-dependent Gene Transcription

Fengxiao Zhang, Yan Wang, Lin Wang, Xi Luo, Kun Huang, Cheng Wang, Meng Du, Fangmei Liu, Ting Luo, Dan Huang, Kai Huang

J Biol Chem. 2013 Apr 19; 288(16): 11348–11357. Published online 2013 Mar 14. doi: 10.1074/jbc.M112.429134

PMCID:: PMC3630903

Abstract Article PDF–2.9M

Srb5/Med18-mediated Termination of Transcription Is Dependent on Gene Looping

Banupriya Mukundan, Athar Ansari

J Biol Chem. 2013 Apr 19; 288(16): 11384–11394. Published online 2013 Mar 8. doi: 10.1074/jbc.M112.446773

PMCID:: PMC3630880

Abstract Article PDF–1.5M

Mechanism of [4Fe-4S](Cys)₄ Cluster Nitrosylation Is Conserved among NO-responsive Regulators

Jason C. Crack, Melanie R. Stapleton, Jeffrey Green, Andrew J. Thomson, Nick E. Le Brun

J Biol Chem. 2013 Apr 19; 288(16): 11492–11502. Published online 2013 Mar 7. doi: 10.1074/jbc.M112.439901

PMCID:: PMC3630887

Abstract Article PDF–2.7M

Cross-species Analysis Reveals Evolving and Conserved Features of the Nuclear Factor κB (NF-κB) Proteins

Grigory Ryzhakov, Ana Teixeira, David Saliba, Katrina Blazek, Tatsushi Muta, Jiannis Ragoussis, Irina A. Udalova

J Biol Chem. 2013 Apr 19; 288(16): 11546–11554. Published online 2013 Mar 18. doi: 10.1074/jbc.M113.451153

PMCID:: PMC3630861

Abstract Article PDF–2.0M

Glycobiology and Extracellular Matrices

Unusual Galactofuranose Modification of a Capsule Polysaccharide in the Pathogenic Yeast Cryptococcus neoformans

Christian Heiss, Michael L. Skowyra, Hong Liu, J. Stacey Klutts, Zhirui Wang, Matthew Williams, Deepa Srikanta, Stephen M. Beverley, Parastoo Azadi, Tamara L. Doering

J Biol Chem. 2013 Apr 19; 288(16): 10994–11003. Published online 2013 Feb 13. doi: 10.1074/jbc.M112.441998

PMCID:: PMC3630864

Abstract Article PDF–2.7M

Structure of a Complex Phosphoglycan Epitope from gp72 of Trypanosoma cruzi

Simon Allen, Julia M. Richardson, Angela Mehlert, Michael A. J. Ferguson

J Biol Chem. 2013 Apr 19; 288(16): 11093–11105. Published online 2013 Feb 22. doi: 10.1074/jbc.M113.452763

PMCID:: PMC3630849

Abstract Article PDF–2.9M

Lipids

Regulation of Expression and Function of Scavenger Receptor Class B, Type I (SR-BI) by Na⁺/H⁺ Exchanger Regulatory Factors (NHERFs)

Zhigang Hu, Jie Hu, Zhonghua Zhang, Wen-Jun Shen, C. Chris Yun, Catherine H. Berlot, Fredric B. Kraemer, Salman Azhar

J Biol Chem. 2013 Apr 19; 288(16): 11416–11435. Published online 2013 Mar 12. doi: 10.1074/jbc.M112.437368

PMCID:: PMC3630890

Abstract Article PDF–3.0M

Expression of Fusion Proteins of Aspergillus terreus Reveals a Novel Allene Oxide Synthase

Inga Hoffmann, Fredrik Jernerén, Ernst H. Oliw

J Biol Chem. 2013 Apr 19; 288(16): 11459–11469. Published online 2013 Mar 11. doi: 10.1074/jbc.M113.458257

PMCID:: PMC3630850

Abstract Article PDF–1.8M

Ceramide Phosphoethanolamine Biosynthesis in Drosophila Is Mediated by a Unique Ethanolamine Phosphotransferase in the Golgi Lumen

Ana M. Vacaru, Joep van den Dikkenberg, Philipp Ternes, Joost C. M. Holthuis

J Biol Chem. 2013 Apr 19; 288(16): 11520–11530. Published online 2013 Feb 28. doi: 10.1074/jbc.M113.460972

PMCID:: PMC3630839

Abstract Article PDF–2.2M

A Unique Sphingolipid Synthase Identified in Drosophila♦: Ceramide Phosphoethanolamine Biosynthesis in Drosophila Is Mediated by a Unique Ethanolamine Phosphotransferase in the Golgi Lumen

J Biol Chem. 2013 Apr 19; 288(16): 11531. doi: 10.1074/jbc.P113.460972

PMCID:: PMC3630851

Article PDF–169K

Membrane Biology

Chitoporin from Vibrio harveyi, a Channel with Exceptional Sugar Specificity

Wipa Suginta, Watcharin Chumjan, Kozhinjampara R. Mahendran, Albert Schulte, Mathias Winterhalter

J Biol Chem. 2013 Apr 19; 288(16): 11038–11046. Published online 2013 Feb 27. doi: 10.1074/jbc.M113.454108

PMCID:: PMC3630896

Abstract Article PDF–1.6M

Differential Roles of the C and N Termini of Orai1 Protein in Interacting with Stromal Interaction Molecule 1 (STIM1) for Ca²⁺ Release-activated Ca²⁺ (CRAC) Channel Activation

Hongying Zheng, Meng-Hua Zhou, Changlong Hu, Enoch Kuo, Xu Peng, Junjie Hu, Lih Kuo, Shenyuan L. Zhang

J Biol Chem. 2013 Apr 19; 288(16): 11263–11272. Published online 2013 Feb 27. doi: 10.1074/jbc.M113.450254

PMCID:: PMC3630893

Abstract Article PDF–2.6M

Structural Sensitivity of a Prokaryotic Pentameric Ligand-gated Ion Channel to Its Membrane Environment

Jonathan M. Labriola, Akash Pandhare, Michaela Jansen, Michael P. Blanton, Pierre-Jean Corringer, John E. Baenziger

J Biol Chem. 2013 Apr 19; 288(16): 11294–11303. Published online 2013 Mar 5. doi: 10.1074/jbc.M113.458133

PMCID:: PMC3630840

Abstract Article PDF–1.3M

A Novel P_1B-type Mn²⁺-transporting ATPase Is Required for Secreted Protein Metallation in Mycobacteria

Teresita Padilla-Benavides, Jarukit E. Long, Daniel Raimunda, Christopher M. Sassetti, José M. Argüello

J Biol Chem. 2013 Apr 19; 288(16): 11334–11347. Published online 2013 Mar 12. doi: 10.1074/jbc.M112.448175

PMCID:: PMC3630897

Abstract Article PDF–3.3M

Impaired Intestinal Calcium Absorption in Protein 4.1R-deficient Mice Due to Altered Expression of Plasma Membrane Calcium ATPase 1b (PMCA1b)

Congrong Liu, Haibao Weng, Lixiang Chen, Shaomin Yang, Hua Wang, Gargi Debnath, Xinhua Guo, Liancheng Wu, Narla Mohandas, Xiuli An

J Biol Chem. 2013 Apr 19; 288(16): 11407–11415. Published online 2013 Mar 4. doi: 10.1074/jbc.M112.436659

PMCID:: PMC3630858

Abstract Article PDF–2.4M

Microbiology

Structural and Functional Characterization of K339T Substitution Identified in the PB2 Subunit Cap-binding Pocket of Influenza A Virus

Yong Liu, Kun Qin, Geng Meng, Jinfang Zhang, Jianfang Zhou, Guangyu Zhao, Ming Luo, Xiaofeng Zheng

J Biol Chem. 2013 Apr 19; 288(16): 11013–11023. Published online 2013 Feb 22. doi: 10.1074/jbc.M112.392878

PMCID:: PMC3630847

Abstract Article PDF–2.0M

The Legionella pneumophila Dot/Icm-secreted Effector PlcC/CegC1 Together with PlcA and PlcB Promotes Virulence and Belongs to a Novel Zinc Metallophospholipase C Family Present in Bacteria and Fungi

Philipp Aurass, Maren Schlegel, Omar Metwally, Clare R. Harding, Gunnar N. Schroeder, Gad Frankel, Antje Flieger

J Biol Chem. 2013 Apr 19; 288(16): 11080–11092. Published online 2013 Mar 1. doi: 10.1074/jbc.M112.426049

PMCID:: PMC3630882

Abstract Article PDF–1.8M

Phosphorylation of Ebola Virus VP30 Influences the Composition of the Viral Nucleocapsid Complex: IMPACT ON VIRAL TRANSCRIPTION AND REPLICATION

Nadine Biedenkopf, Bettina Hartlieb, Thomas Hoenen, Stephan Becker

J Biol Chem. 2013 Apr 19; 288(16): 11165–11174. Published online 2013 Mar 14. doi: 10.1074/jbc.M113.461285

PMCID:: PMC3630872

Abstract Article PDF–1.9M

An Electron-bifurcating Caffeyl-CoA Reductase

Johannes Bertsch, Anutthaman Parthasarathy, Wolfgang Buckel, Volker Müller

J Biol Chem. 2013 Apr 19; 288(16): 11304–11311. Published online 2013 Mar 11. doi: 10.1074/jbc.M112.444919

PMCID:: PMC3630892

Abstract Article PDF–812K

Biochemical and Biophysical Properties of a Putative Hub Protein Expressed by Vaccinia Virus

Nicole E. Kay, Travis W. Bainbridge, Richard C. Condit, Michael R. Bubb, Reuben E. Judd, Balasubramanian Venkatakrishnan, Robert McKenna, Susan M. D'Costa

J Biol Chem. 2013 Apr 19; 288(16): 11470–11481. Published online 2013 Mar 8. doi: 10.1074/jbc.M112.442012

PMCID:: PMC3630899

Abstract Article PDF–1.9M

Molecular Bases of Disease

A Cardiac-enriched MicroRNA, miR-378, Blocks Cardiac Hypertrophy by Targeting Ras Signaling

Raghu S. Nagalingam, Nagalingam R. Sundaresan, Mahesh P. Gupta, David L. Geenen, R. John Solaro, Madhu Gupta

J Biol Chem. 2013 Apr 19; 288(16): 11216–11232. Published online 2013 Feb 27. doi: 10.1074/jbc.M112.442384

Retraction in:: J Biol Chem. 2017 Mar 24; 292(12): 5123.

PMCID:: PMC3630862

Abstract Article

Secretory Defect and Cytotoxicity: THE POTENTIAL DISEASE MECHANISMS FOR THE RETINITIS PIGMENTOSA (RP)-ASSOCIATED INTERPHOTORECEPTOR RETINOID-BINDING PROTEIN (IRBP)

Songhua Li, Zhihui Yang, Jane Hu, William C. Gordon, Nicolas G. Bazan, Arthur L. Haas, Dean Bok, Minghao Jin

J Biol Chem. 2013 Apr 19; 288(16): 11395–11406. Published online 2013 Mar 13. doi: 10.1074/jbc.M112.418251

PMCID:: PMC3630842

Abstract Article PDF–3.5M

Sequential Inductions of the ZEB1 Transcription Factor Caused by Mutation of Rb and Then Ras Proteins Are Required for Tumor Initiation and Progression

Yongqing Liu, Ester Sánchez-Tilló, Xiaoqin Lu, Li Huang, Brian Clem, Sucheta Telang, Alfred B. Jenson, Miriam Cuatrecasas, Jason Chesney, Antonio Postigo, Douglas C. Dean

J Biol Chem. 2013 Apr 19; 288(16): 11572–11580. Published online 2013 Feb 26. doi: 10.1074/jbc.M112.434951

PMCID:: PMC3630860

Abstract Article PDF–1.7M

Self-catalytic DNA Depurination Underlies Human β-Globin Gene Mutations at Codon 6 That Cause Anemias and Thalassemias

Juan R. Alvarez-Dominguez, Olga Amosova, Jacques R. Fresco

J Biol Chem. 2013 Apr 19; 288(16): 11581–11589. Published online 2013 Mar 2. doi: 10.1074/jbc.M113.454744

PMCID:: PMC3630879

Abstract Article PDF–1.7M

Molecular Biophysics

Pore Helices Play a Dynamic Role as Integrators of Domain Motion during Kv11.1 Channel Inactivation Gating

Matthew D. Perry, Chai Ann Ng, Jamie I. Vandenberg

J Biol Chem. 2013 Apr 19; 288(16): 11482–11491. Published online 2013 Mar 7. doi: 10.1074/jbc.M113.461442

PMCID:: PMC3630859

Abstract Article PDF–1.2M

Neurobiology

Aminothienopyridazines and Methylene Blue Affect Tau Fibrillization via Cysteine Oxidation

Alex Crowe, Michael J. James, Virginia M.-Y. Lee, Amos B. Smith, III, John Q. Trojanowski, Carlo Ballatore, Kurt R. Brunden

J Biol Chem. 2013 Apr 19; 288(16): 11024–11037. Published online 2013 Feb 26. doi: 10.1074/jbc.M112.436006

PMCID:: PMC3630889

Abstract Article PDF–2.7M

An Intracellular Domain Fragment of the p75 Neurotrophin Receptor (p75^NTR) Enhances Tropomyosin Receptor Kinase A (TrkA) Receptor Function

Dusan Matusica, Sune Skeldal, Alex M. Sykes, Nickless Palstra, Aanchal Sharma, Elizabeth J. Coulson

J Biol Chem. 2013 Apr 19; 288(16): 11144–11154. Published online 2013 Mar 7. doi: 10.1074/jbc.M112.436469

PMCID:: PMC3630867

Abstract Article PDF–2.8M

Impact of Sustained Exposure to β-Amyloid on Calcium Homeostasis and Neuronal Integrity in Model Nerve Cell System Expressing α4β2 Nicotinic Acetylcholine Receptors

Komal Arora, Naghum Alfulaij, Jason K. Higa, Jun Panee, Robert A. Nichols

J Biol Chem. 2013 Apr 19; 288(16): 11175–11190. Published online 2013 Mar 11. doi: 10.1074/jbc.M113.453746

PMCID:: PMC3630845

Abstract Article PDF–5.9M

Protein Structure and Folding

The TP0796 Lipoprotein of Treponema pallidum Is a Bimetal-dependent FAD Pyrophosphatase with a Potential Role in Flavin Homeostasis

Ranjit K. Deka, Chad A. Brautigam, Wei Z. Liu, Diana R. Tomchick, Michael V. Norgard

J Biol Chem. 2013 Apr 19; 288(16): 11106–11121. Published online 2013 Feb 27. doi: 10.1074/jbc.M113.449975

PMCID:: PMC3630870

Abstract Article PDF–2.1M

Crystal Structures of Matriptase in Complex with Its Inhibitor Hepatocyte Growth Factor Activator Inhibitor-1

Baoyu Zhao, Cai Yuan, Rui Li, Dan Qu, Mingdong Huang, Jacky Chi Ki Ngo

J Biol Chem. 2013 Apr 19; 288(16): 11155–11164. Published online 2013 Feb 26. doi: 10.1074/jbc.M113.454611

PMCID:: PMC3630853

Abstract Article PDF–1.9M

Structural Units Important for Activity of a Novel-type Phosphoserine Phosphatase from Hydrogenobacter thermophilus TK-6 Revealed by Crystal Structure Analysis

Yoko Chiba, Shoichiro Horita, Jun Ohtsuka, Hiroyuki Arai, Koji Nagata, Yasuo Igarashi, Masaru Tanokura, Masaharu Ishii

J Biol Chem. 2013 Apr 19; 288(16): 11448–11458. Published online 2013 Mar 11. doi: 10.1074/jbc.M112.449561

PMCID:: PMC3630900

Abstract Article PDF–2.7M

Protein Synthesis and Degradation

Allosteric Transitions Direct Protein Tagging by PafA, the Prokaryotic Ubiquitin-like Protein (Pup) Ligase

Naomi Ofer, Nadav Forer, Maayan Korman, Marina Vishkautzan, Isam Khalaila, Eyal Gur

J Biol Chem. 2013 Apr 19; 288(16): 11287–11293. Published online 2013 Mar 7. doi: 10.1074/jbc.M112.435842

PMCID:: PMC3630894

Abstract Article PDF–999K

Signal Transduction

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Is a Second Messenger in Muscarinic Receptor-induced Contraction of Guinea Pig Trachea

Parvinder K. Aley, Nisha Singh, G. Cristina Brailoiu, Eugen Brailoiu, Grant C. Churchill

J Biol Chem. 2013 Apr 19; 288(16): 10986–10993. Published online 2013 Mar 6. doi: 10.1074/jbc.M113.458620

PMCID:: PMC3630863

Abstract Article PDF–1.1M

Platelet-derived Growth Factor-BB Activates Calcium/Calmodulin-dependent and -independent Mechanisms That Mediate Akt Phosphorylation in the Neurofibromin-deficient Human Schwann Cell Line ST88-14

Robert G. Farrer, Jason R. Farrer, George H. DeVries

J Biol Chem. 2013 Apr 19; 288(16): 11066–11073. Published online 2013 Mar 1. doi: 10.1074/jbc.M112.442244

PMCID:: PMC3630876

Abstract Article PDF–1.1M

Fragmented Inositol 1,4,5-Trisphosphate Receptors Retain Tetrameric Architecture and Form Functional Ca²⁺ Release Channels

Kamil J. Alzayady, Rahul Chandrasekhar, David I. Yule

J Biol Chem. 2013 Apr 19; 288(16): 11122–11134. Published online 2013 Mar 11. doi: 10.1074/jbc.M113.453241

PMCID:: PMC3630841

Abstract Article PDF–3.2M

Transactivation of the PAR1-PAR2 Heterodimer by Thrombin Elicits β-Arrestin-mediated Endosomal Signaling

Huilan Lin, JoAnn Trejo

J Biol Chem. 2013 Apr 19; 288(16): 11203–11215. Published online 2013 Mar 8. doi: 10.1074/jbc.M112.439950

PMCID:: PMC3630854

Abstract Article PDF–3.5M

Activated RhoA Is a Positive Feedback Regulator of the Lbc Family of Rho Guanine Nucleotide Exchange Factor Proteins

Frank Medina, Angela M. Carter, Olugbenga Dada, Stephen Gutowski, Jana Hadas, Zhe Chen, Paul C. Sternweis

J Biol Chem. 2013 Apr 19; 288(16): 11325–11333. Published online 2013 Mar 14. doi: 10.1074/jbc.M113.450056

PMCID:: PMC3630898

Abstract Article PDF–2.3M

Ras Protein/cAMP-dependent Protein Kinase Signaling Is Negatively Regulated by a Deubiquitinating Enzyme, Ubp3, in Yeast

Yang Li, Yuqi Wang

J Biol Chem. 2013 Apr 19; 288(16): 11358–11365. Published online 2013 Mar 8. doi: 10.1074/jbc.M112.449751

PMCID:: PMC3630878

Abstract Article PDF–1.6M

Ribotoxic Stress through p38 Mitogen-activated Protein Kinase Activates in Vitro the Human Pyrin Inflammasome

Je-Wook Yu, Andrew Farias, Inhwa Hwang, Teresa Fernandes-Alnemri, Emad S. Alnemri

J Biol Chem. 2013 Apr 19; 288(16): 11378–11383. Published online 2013 Mar 11. doi: 10.1074/jbc.M112.448795

PMCID:: PMC3630843

Abstract Article PDF–1.9M

Additions and Corrections

BID-D59A is a potent inducer of apoptosis in primary embryonic fibroblasts.

Rachel Sarig, Yehudit Zaltsman, Richard C. Marcellus, Richard Flavell, Tak W. Mak, Atan Gross

J Biol Chem. 2013 Apr 19; 288(16): 11503. doi: 10.1074/jbc.A113.210296

Corrects:: J Biol Chem. 2003 Mar 21; 278(12): 10707–10715.

PMCID:: PMC3630904

Correction PDF–48K

Maria K. Traver, Stanley C. Henry, Viviana Cantillana, Tim Oliver, Julia P. Hunn, Jonathan C. Howard, Sandra Beer, Klaus Pfeffer, Jörn Coers, Gregory A. Taylor

J Biol Chem. 2013 Apr 19; 288(16): 11504. doi: 10.1074/jbc.A111.251967

Corrects:: J Biol Chem. 2011 Sep 2; 286(35): 30471–30480.

PMCID:: PMC3630884

Correction PDF–48K

Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing Tn antigen.

Rongjuan Mi, Lina Song, Yingchun Wang, Xiaokun Ding, Junwei Zeng, Sylvain Lehoux, Rajindra P. Aryal, Jianmei Wang, Vanja K. Crew, Irma van Die, Arlene B. Chapman, Richard D. Cummings, Tongzhong Ju

J Biol Chem. 2013 Apr 19; 288(16): 11505. doi: 10.1074/jbc.A112.371989