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Volume 4;  2011

Original Research

FAM13A locus in COPD is independently associated with lung cancer – evidence of a molecular genetic link between COPD and lung cancer
Robert P Young, Raewyn J Hopkins, Bryan A Hay, Chris F Whittington, Michael J Epton, Gregory D Gamble
Appl Clin Genet. 2011; 4: 1–10. Published online 2010 Dec 22. doi: 10.2147/TACG.S15758
PMCID:
PMC3681173
Abstract Article PDF–577K
DataGenno: building a new tool to bridge molecular and clinical genetics
Fabricio F Costa, Luciano S Foly, Marcelo P Coutinho
Appl Clin Genet. 2011; 4: 45–54. Published online 2011 Mar 18. doi: 10.2147/TACG.S17597
PMCID:
PMC3681177
Abstract Article PDF–1.8M
GSTM1 null genotype in COPD and lung cancer: evidence of a modifier or confounding effect?
Robert P Young, Raewyn J Hopkins, Bryan A Hay, Gregory D Gamble
Appl Clin Genet. 2011; 4: 137–144. Published online 2011 Sep 13. doi: 10.2147/TACG.S21517
PMCID:
PMC3681185
Abstract Article PDF–219K

Reviews

The genetics of breast cancer: risk factors for disease
Andrew Collins, Ioannis Politopoulos
Appl Clin Genet. 2011; 4: 11–19. Published online 2011 Jan 7. doi: 10.2147/TACG.S13139
PMCID:
PMC3681174
Abstract Article PDF–172K
Interleukin-1β inhibitors for the treatment of cryopyrin-associated periodic syndrome
Eugen Dhimolea
Appl Clin Genet. 2011; 4: 21–27. Published online 2011 Jan 26. doi: 10.2147/TACG.S8146
PMCID:
PMC3681175
Abstract Article PDF–133K
Novel compounds for the treatment of Duchenne muscular dystrophy: emerging therapeutic agents
Steve D Wilton, Sue Fletcher
Appl Clin Genet. 2011; 4: 29–44. Published online 2011 Mar 10. doi: 10.2147/TACG.S8762
PMCID:
PMC3681176
Abstract Article PDF–240K
Alpha1-antitrypsin deficiency: a clinical-genetic overview
Raja T Abboud, Tanya N Nelson, Benjamin Jung, Andre Mattman
Appl Clin Genet. 2011; 4: 55–65. Published online 2011 Mar 31. doi: 10.2147/TACG.S10604
PMCID:
PMC3681178
Abstract Article PDF–186K
Genetic basis of Parkinson’s disease: inheritance, penetrance, and expression
Claudia Schulte, Thomas Gasser
Appl Clin Genet. 2011; 4: 67–80. Published online 2011 Jun 1. doi: 10.2147/TACG.S11639
PMCID:
PMC3681179
Abstract Article PDF–685K
Identifying the genetic components underlying the pathophysiology of movement disorders
Mario Ezquerra, Yaroslau Compta, Maria J Marti
Appl Clin Genet. 2011; 4: 81–92. Published online 2011 Jun 23. doi: 10.2147/TACG.S7333
PMCID:
PMC3681180
Abstract Article PDF–200K
Genetic variations and associated pathophysiology in the management of epilepsy
John C Mulley, Leanne M Dibbens
Appl Clin Genet. 2011; 4: 113–125. Published online 2011 Aug 8. doi: 10.2147/TACG.S7407
PMCID:
PMC3681183
Abstract Article PDF–213K
N-acetylglutamate synthase deficiency: an insight into the genetics, epidemiology, pathophysiology, and treatment
Nicholas Ah Mew, Ljubica Caldovic
Appl Clin Genet. 2011; 4: 127–135. Published online 2011 Aug 24. doi: 10.2147/TACG.S12702
PMCID:
PMC3681184
Abstract Article PDF–214K
Inherited and acquired alterations in development of breast cancer
Piera Rizzolo, Valentina Silvestri, Mario Falchetti, Laura Ottini
Appl Clin Genet. 2011; 4: 145–158. Published online 2011 Nov 14. doi: 10.2147/TACG.S13226
PMCID:
PMC3681186
Abstract Article PDF–288K

Case Report

A Lebanese family with autosomal recessive oculo-auriculo-vertebral (OAV) spectrum and review of the literature: is OAV a genetically heterogeneous disorder?
Chantal Farra, Khaled Yunis, Nadine Yazbeck, Marianne Majdalani, Lama Charafeddine, Rima Wakim, Johnny Awwad
Appl Clin Genet. 2011; 4: 93–97. Published online 2011 Jul 6. doi: 10.2147/TACG.S12643
PMCID:
PMC3681181
Abstract Article PDF–129K

Perspectives

Genetic evidence linking lung cancer and COPD: a new perspective
Robert P Young, Raewyn J Hopkins, Gregory D Gamble, Carol Etzel, Randa El-Zein, James D Crapo
Appl Clin Genet. 2011; 4: 99–111. Published online 2011 Jul 18. doi: 10.2147/TACG.S20083
PMCID:
PMC3681182
Abstract Article PDF–317K
Articles from The Application of Clinical Genetics are provided here courtesy of Dove Press
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