Volume 15(10); 2013 Oct

Research Articles

Acid-Mediated Tumor Proteolysis: Contribution of Cysteine Cathepsins

Jennifer M Rothberg, Kate M Bailey, Jonathan W Wojtkowiak, Yael Ben-Nun, Matthew Bogyo, Ekkehard Weber, Kamiar Moin, Galia Blum, Raymond R Mattingly, Robert J Gillies, Bonnie F Sloane

Neoplasia. 2013 Oct; 15(10): 1125–1137. doi: 10.1593/neo.13946

Correction in:: Neoplasia. 2013 Oct; 15(10): erratum.

PMCID:: PMC3819629

Abstract Article PDF–8.6M

Molecular Characterization of Patient-Derived Human Pancreatic Tumor Xenograft Models for Preclinical and Translational Development of Cancer Therapeutics

Mike Mattie, Ashley Christensen, Mi Sook Chang, William Yeh, Suzanne Said, Yuriy Shostak, Linnette Capo, Alla Verlinsky, Zili An, Ingrid Joseph, Yi Zhang, Sathish Kumar-Ganesan, Karen Morrison, David Stover, Pia Challita-Eid

Neoplasia. 2013 Oct; 15(10): 1138–1150. doi: 10.1593/neo.13922

Correction in:: Neoplasia. 2013 Oct; 15(10): erratum.

PMCID:: PMC3819630

Abstract Article PDF–5.1M

Dependence of Tumor Cell Lines and Patient-Derived Tumors on the NAD Salvage Pathway Renders Them Sensitive to NAMPT Inhibition with GNE-618

Yang Xiao, Kristi Elkins, Jenni K Durieux, Leslie Lee, Jason Oeh, Lulu X Yang, Xiaorong Liang, Chris DelNagro, Jarrod Tremayne, Mandy Kwong, Bianca M Liederer, Peter K Jackson, Lisa D Belmont, Deepak Sampath, Thomas O'Brien

Neoplasia. 2013 Oct; 15(10): 1151–1160. doi: 10.1593/neo.131304

Correction in:: Neoplasia. 2013 Oct; 15(10): erratum.

PMCID:: PMC3819631

Abstract Article PDF–1.8M

Allosteric MEK1/2 Inhibitor Refametinib (BAY 86-9766) in Combination with Sorafenib Exhibits Antitumor Activity in Preclinical Murine and Rat Models of Hepatocellular Carcinoma

Roberta Schmieder, Florian Puehler, Roland Neuhaus, Maria Kissel, Alex A Adjei, Jeffrey N Miner, Dominik Mumberg, Karl Ziegelbauer, Arne Scholz

Neoplasia. 2013 Oct; 15(10): 1161–1171. doi: 10.1593/neo.13812

Correction in:: Neoplasia. 2013 Oct; 15(10): erratum.

PMCID:: PMC3819632

Abstract Article PDF–2.6M

Combination of the PI3K Inhibitor ZSTK474 with a PSMA-Targeted Immunotoxin Accelerates Apoptosis and Regression of Prostate Cancer

Daniele Baiz, Sazzad Hassan, Young A Choi, Anabel Flores, Yelena Karpova, Dana Yancey, Ashok Pullikuth, Guangchao Sui, Michel Sadelain, Waldemar Debinski, George Kulik

Neoplasia. 2013 Oct; 15(10): 1172–1183. doi: 10.1593/neo.13986

Correction in:: Neoplasia. 2013 Oct; 15(10): erratum.

PMCID:: PMC3819633

Abstract Article PDF–5.8M

A Novel Ras Inhibitor (MDC-1016) Reduces Human Pancreatic Tumor Growth in Mice

Gerardo G Mackenzie, Lauren E Bartels, Gang Xie, Ioannis Papayannis, Ninche Alston, Kvetoslava Vrankova, Nengtai Ouyang, Basil Rigas

Neoplasia. 2013 Oct; 15(10): 1184–1195. doi: 10.1593/neo.131368

Correction in:: Neoplasia. 2013 Oct; 15(10): erratum.

PMCID:: PMC3819634

Abstract Article PDF–2.4M

Sym004, a Novel EGFR Antibody Mixture, Can Overcome Acquired Resistance to Cetuximab

Mari Iida, Toni M Brand, Megan M Starr, Chunrong Li, Evan J Huppert, Neha Luthar, Mikkel W Pedersen, Ivan D Horak, Michael Kragh, Deric L Wheeler

Neoplasia. 2013 Oct; 15(10): 1196–1206. doi: 10.1593/neo.131584

Correction in:: Neoplasia. 2013 Oct; 15(10): erratum.

PMCID:: PMC3819635

Abstract Article PDF–1.4M

Targeted Radiosensitization of ETS Fusion-Positive Prostate Cancer through PARP1 Inhibition

Sumin Han, J Chad Brenner, Aaron Sabolch, Will Jackson, Corey Speers, Kari Wilder-Romans, Karen E Knudsen, Theodore S Lawrence, Arul M Chinnaiyan, Felix Y Feng

Neoplasia. 2013 Oct; 15(10): 1207–1217. doi: 10.1593/neo.131604